CD70 Protein (mouse), hFc Tag

Description: Recombinant mouse CD70 protein with N-terminal human Fc tag Background: Predicted to enable cytokine activity and protease binding activity. Predicted to be involved in several processes, including B cell proliferation, T cell mediated immunity, and extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in Meckel's cartilage, hip, and skeleton. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule). [provided by Alliance of Genome Resources, Apr 2022] Description: Recombinant mouse CD70 protein with N-terminal human Fc tag Molecular Characterization: hFc(Glu99-Ala330) Mouse CD70(Ser45-Pro195) Molecular Weight: The protein has a predicted molecular mass of 42.8 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mCD70 is approximately 35-70 kDa due to glycosylation. Tag: N-Human Fc Tag Protein function: Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. [The UniProt Consortium]