ZDHHC21 (Vector pUC, Accession No. BC042558)

Length: 798 Sequence: atgggtctcc ggattcactt tgttgttgac ccacatggtt ggtgctgcat gggtttgatt gtctttgttt ggttatacaa tattgtttta attcccaaaa ttgtcctctt tcctcactat gaagaaggac atattccagg catattaata ataatattct atggcatttc catattctgt ctggttgcct tagtgagggc ctccataact gatccaggaa gactccctga gaaccccaag atcccacatg gagaaaggga gttctgggaa ttatgtaaca agtgtaattt gatgagacca aagcgttccc atcactgcag ccgctgcggc cactgtgtga ggagaatgga tcatcactgt ccatggatta acaattgtgt tggtgaagat aatcattggc tctttctgca gttgtgtttc tacactgaac ttcttacttg ctacgcactg atgttttctt tctgccacta ttactatttt cttccactaa aaaagcgtaa tttggacctc tttgttttta gacatgaatt ggccataatg agactagcag cctttatggg cattactatg ttagttggaa taactggact cttttacact caactaattg gcatcatcac agatacaaca tctattgaaa agatgtcaaa ctgttgtgaa gatatatcga ggccccgaaa gccatggcag cagaccttct cagaagtttt tggcactcgt tggaagatcc tgtggttcat tcctttcagg cagaggcaac cactgcgagt tccctaccac tttgccaatc Protein function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296). This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK. [The UniProt Consortium]