ZBTB7B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1620 Sequence: atggggagcc ccgaggatga cctgattggg attccattcc cggaccacag cagtgagctc ctgagctgcc tcaatgagca gcgccagctg ggccacctat gtgacctcac catccggacg cagggccttg aataccgcac ccacagggct gtgctagctg cctgtagcca ctacttcaag aagcttttca ctgagggcgg tggcggagct gtcatggggg ccgggggtag cgggacggcc actgggggag caggggccgg tgtgtgtgag ctggactttg tagggccaga ggcactaggc gccctccttg aatttgccta tacagccaca ctgaccacca gcagcgccaa catgccagct gtgctccagg ctgcccgcct gctggagatt ccgtgtgtca tcgctgcttg catggagatt ctgcagggca gtgggctaga agctcccagc ccggacgagg atgactgtga gcgagcccgc cagtatctgg aggcctttgc cacagccacg gcctctggag ttcccaatgg tgaagacagt cctccacagg tgcccctccc accacctccg ccaccgccac ctcggcctgt tgcccgccgc agccgcaagc cccggaaagc tttcctgcaa accaaggggg ccagagcaaa ccacctagtc cctgaggtgc ccacagtgcc cgcccatccc ttgacctatg aggaggagga ggtggcgggc agagtgggca gcagtggggg cagtgggccg ggggacagct acagccctcc cacaggaact gcctcccctc ctgagggtcc ccagagctac gaaccctatg agggtgagga agaagaagag gagctggtat atcccccagc ctatgggctg gcgcagggtg gcgggccccc gctgtcccca gaggagctgg gctcagatga ggatgccatc gatcctgacc tgatggccta cctaagctcc ctgcaccagg acaacctggc accaggcctg gacagccaag acaagctggt gcgcaaacgc cgctcccaga tgcctcagga gtgccctgtc tgccacaaga tcatccatgg ggcaggcaaa ctgcctcgcc acatgaggac ccacacaggc gagaagccct ttgcctgcga ggtctgcggt gttcgattca ccaggaacga caagctgaag atccacatgc ggaagcacac gggagagcgc ccctactcat gcccgcactg cccagcccgc ttcctgcaca gctacgacct caagaaccac atgcacctgc acacagggga ccggccctat gagtgccacc tgtgccacaa ggctttcgcc aaggaggacc acctgcagcg ccacctcaaa ggccagaact gcctggaggt gcgcacccga cggcgccgca aggacgatgc accaccccac tacccgccac cctctaccgc tgctgcatcc cccgctggcc tcgacctctc caatggccac ctggacacct tccgcctctc tctagctcga ttctgggagc agtcagcccc cactgggccc ccggtctcta ccccagggcc ccctgatgac gatgaggagg aaggggcacc caccacaccc caggctgaag gtgccatgga Protein function: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes. [The UniProt Consortium]