YES1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1632 Sequence: atgggctgca ttaaaagtaa agaaaacaaa agtccagcca ttaaatacag acctgaaaat actccagagc ctgtcagtac aagtgtgagc cattatggag cagaacccac tacagtgtca ccatgtccgt catcttcagc aaagggaaca gcagttaatt tcagcagtct ttccatgaca ccatttggag gatcctcagg ggtaacgcct tttggaggtg catcttcctc attttcagtg gtgccaagtt catatcctgc tggtttaaca ggtggtgtta ctatatttgt ggccttatat gattatgaag ctagaactac agaagacctt tcatttaaga agggtgaaag atttcaaata attaacaata cggaaggaga ttggtgggaa gcaagatcaa tcgctacagg aaagaatggt tatatcccga gcaattatgt agcgcctgca gattccattc aggcagaaga atggtatttt ggcaaaatgg ggagaaaaga tgctgaaaga ttacttttga atcctggaaa tcaacgaggt attttcttag taagagagag tgaaacaact aaaggtgctt attccctttc tattcgtgat tgggatgaga taaggggtga caatgtgaaa cactacaaaa ttaggaaact tgacaatggt ggatactata tcacaaccag agcacaattt gatactctgc agaaattggt gaaacactac acagaacatg ctgatggttt atgccacaag ttgacaactg tgtgtccaac tgtgaaacct cagactcaag gtctagcaaa agatgcttgg gaaatccctc gagaatcttt gcgactagag gttaaactag gacaaggatg tttcggcgaa gtgtggatgg gaacatggaa tggaaccacg aaagtagcaa tcaaaacact aaaaccaggt acaatgatgc cagaagcttt ccttcaagaa gctcagataa tgaaaaaatt aagacatgat aaacttgttc cactatatgc tgttgtttct gaagaaccaa tttacattgt cactgaattt atgtcaaaag gaagcttatt agatttcctt aaggaaggag atggaaagta tttgaagctt ccacagctgg ttgatatggc tgctcagatt gctgatggta tggcatatat tgaaagaatg aactatattc accgagatct tcgggctgct aatattcttg taggagaaaa tcttgtgtgc aaaatagcag actttggttt agcaaggtta attgaagaca atgaatacac agcaagacaa ggtgcaaaat ttccaatcaa atggacagct cctgaagctg cactgtatgg tcggtttaca ataaagtctg atgtctggtc atttggaatt ctgcaaacag aactagtaac aaagggccga gtgccatatc caggtatggt gaaccgtgaa gtactagaac aagtggagcg aggatacagg atgccgtgcc ctcagggctg tccagaatcc ctccatgaat tgatgaatct gtgttggaag aaggaccctg atgaaagacc aacatttgaa tatattcagt ccttcttgga agactacttc actgctacag agccacagta ccagccagga gaaaatttat Protein function: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. [The UniProt Consortium]