USP5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2508 Sequence: atggcggagc tgagtgagga ggcgctgctg tcagtattac cgacgatccg ggtccctaag gctggagacc gggtccacaa agacgagtgc gccttctcct tcgacacgcc ggagtctgag gggggcctct acatctgtat gaacacgttt ctgggctttg ggaaacagta tgtggagaga catttcaata agaccggcca gcgagtctac ttgcacctcc ggcggacccg gcgcccgaaa gaggaggacc ctgctacagg cactggagac ccaccccgga agaagcccac gcggctggct attggtgttg aaggcggatt tgaccttagc gaggagaagt ttgaattaga cgaggatgtg aagattgtca ttttgccaga ttacctggag attgcccggg atggactggg gggactgcct gacattgtca gagatcgggt gaccagtgca gtggaggccc tactgtcggc cgactcagcc tcccgcaagc aggaggtgca ggcatgggat ggggaagtac ggcaggtgtc taagcatgcc ttcagcctca agcagttgga caaccctgct cgaatccctc cctgtggctg gaagtgctcc aagtgtgaca tgagagagaa cctgtggctc aacctgactg atggctccat cctctgtggg cgacgctact tcgatggcag tgggggcaac aaccacgctg tggagcacta ccgagagaca ggctacccgt tagctgtcaa gctgggcacc atcacccctg atggagctga cgtgtactca tatgatgagg atgacatggt cctggacccc agcctggctg agcacctgtc ccacttcggc atcgacatgc tgaagatgca gaagacagac aagacgatga ctgagttgga gatagacatg aaccagcgga ttggtgaatg ggagctgatc caggagtcag gtgtgccact caagcccctg tttgggcctg gctacacagg catccggaac ctgggtaaca gctgctacct caactctgtg gtccaggtgc tcttcagcat ccctgacttc cagaggaagt atgtggataa gctggagaag atcttccaga atgccccgac ggaccctacc caggatttca gcacccaggt ggccaagctg ggccatggcc ttctctccgg ggagtattcc aagccagtac cggagtcggg cgatggggag cgggtgccag aacagaagga agttcaagat ggcattgccc ctcggatgtt caaggccctc atcggcaagg gccaccctga attctccacc aaccggcagc aggatgccca ggagttcttc cttcacctta tcaacatggt ggagaggaat tgccggagct ctgaaaatcc taatgaagtg ttccgcttct tggtggagga aaagatcaag tgcctggcca cagagaaggt gaagtacacc cagcgagttg actacatcat gcagctgcct gtgcccatgg atgcagccct taacaaagag gagcttctgg agtacgagga gaagaagcgg caagccgaag aggagaagat ggcactgcca gaactggttc gggcccaggt gcccttcagc tcttgcctgg aggcctacgg ggcccctgag caggtcgatg acttctggag cacggccctg caggccaagt cagtagctgt caagaccaca cgatttgcct cattccctga ctacctggtc atccagatca agaagttcac cttcggctta gactgggtgc ccaagaaact ggatgtgtcc atcgagatgc cagaggagct cgacatctcc cagttgaggg gcacagggct gcagcccgga gaggaggagc tgccagacat tgccccaccc ctggtcactc cggatgagcc caaagcgccc atgctggatg aatcagtcat catccagctg gtggagatgg gattccctat ggacgcctgc cgcaaagctg tctactacac gggcaacagc ggggctgagg ccgccatgaa ctgggtcatg tcacacatgg atgatccaga ttttgcaaac cccctcatcc tgcctggctc tagtgggccg ggctccacaa gcgcagcagc cgacccccct cctgaggact gtgtgaccac cattgtctcc atgggcttct cccgggacca ggccttgaaa gcgctgcggg ccacgaacaa tagtttagaa cgggctgtgg actggatctt cagtcacatt gacgacctgg atgctgaagc tgccatggac atctcagagg gccgctcagc tgccgactcc atctctgagt ctgtgccagt gggacctaaa gtccgggatg gtcctggaaa gtatcagctc tttgccttca ttagtcacat gggcacctct accatgtgtg gtcactacgt ctgccacatc aagaaagaag gcagatgggt gatctacaat gaccagaaag tgtgtgcctc cgagaagccg cccaaggacc tgggctacat ctacttctac cagagagtgg Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [The UniProt Consortium]