TMTC3 (Vector pUC, Accession No. BC117175)

Length: 2745 Sequence: atggctaata ttaacctaaa agaaataacc ttaatagtag gtgtggttac tgcctgctat tggaacagcc tcttttgtgg ttttgttttt gatgatgttt cagcaatact ggataacaaa gacttgcatc catctacacc tttaaaaact ttatttcaaa atgacttctg gggaacccct atgtctgagg agagaagcca caagtcttac cgtcccttaa cagtattgac atttcgctta aattatttgt taagtgaact aaaaccaatg tcatatcatc tcctgaatat gatttttcat gctgtggtta gtgtgatatt tctcaaagta tgcaaacttt ttctggacaa caagagtagt gtgattgctt ctttactttt tgcagtgcac ccaatacaca cagaagcagt aacaggagtt gttggaagag cagaactttt gtcatctatc ttttttctag cagctttttt gtcatatacc agatcaaaag gaccagacaa ttccataata tggactccaa ttgccttgac agtgttttta gtggctgttg caacattatg taaagaacaa ggaataacag ttgtaggaat ttgctgtgtg tatgaagtgt ttattgccca ggggtatact ttgccattac tatgtactac tgctggacag tttctccgtg gaaagggtag cattccattt tctatgctgc agacactagt aaaactcatt gtcttgatgt tcagtacatt attacttgtt gtgattagag tccaggttat tcaatcccaa cttccagtat tcaccaggtt tgataaccca gctgctgtaa gcccaactcc tacaaggcaa ctaactttta actacctcct tcctgtgaat gcttggttgt tattaaatcc ttcagagctc tgctgtgatt ggaccatggg aacaatacca cttatagagt cattactaga tattcgaaat ctggccacat ttactttctt ttgttttctg gggatgttgg gagtattcag tatcagatac tctggtgatt cctccaagac tgttttaatg gcgctttgtt taatggcatt accatttatt cctgcatcga accttttttt tccagttgga tttgttgttg ccgagcgagt attatatgtt cccagcatgg ggttctgtat tttggtagcc catggatggc agaaaatatc aacaaaaagt gtatttaaaa agctatcctg gatttgtctg tctatggtga tactcactca ttccttaaaa acattccaca gaaattggga ttgggagtct gaatatacat tgtttatgtc agccttgaag gtaaataaaa ataatgccaa actttggaat aatgtgggtc atgctctgga aaatgaaaag aactttgaga gagctttgaa atacttctta caggctaccc atgttcagcc agatgatatt ggtgcccata tgaatgtagg aagaacttat aaaaatttaa atagaaccaa agaagctgaa gaatcttaca tgatggctaa atcactgatg cctcaaatta ttcctggtaa aaaatatgca gccagaattg cccctaacca cctaaatgtt tatatcaatc tggctaacct gatccgagca aatgagtccc gactggaaga agcagatcag ctgtaccgtc aagcaataag catgaggccc gacttcaagc aggcttacat tagcagagga gaattgcttt taaaaatgaa taaacctctt aaagcaaagg aagcatatct taaagcacta gagctggaca gaaataatgc agatctttgg tacaacttgg caattgtaca tattgaactt aaagaaccaa atgaagccct aaaaaacttt aatcgtgctc tggaactaaa tccaaagcat aaactagcat tattcaactc tgctatagta atgcaagaat caggtgaggt taaactcaga cctgaagcta gaaaacgact tctaagttat ataaatgaag agccactaga tgctaatggg tatttcaatt tgggaatgct tgccatggat gacaaaaagg acaatgaagc agagatttgg atgaagaaag ccataaagtt acaagccgac ttccgaagtg ctttgtttaa tctggctctc ctgtattccc agactgcaaa ggaattaaag gctttgccaa ttttggagga gttactcaga tactaccctg atcatatcaa gggcctcatt ttaaaaggag acattctgat gaatcaaaag aaagatatac taggagcaaa aaaatgtttt gaaaggattt tggagatgga tccaagcaat gtgcaaggaa aacacaatct ttgtgttgtt tattttgaag aaaaagactt attaaaagct gaaagatgcc ttcttgaaac actggcatta gcaccacatg aagaatatat tcagcgccat ttgaatatag tcagggataa gatttcctca tctagtttta tagagccaat attcccaacc agtaagattt caagtgtgga aggaaagaaa attccaactg aaagtgtaaa agaaattaga ggtgaatcca gacaaacaca aatagtaaaa acaagtgata ataaaagtca gtctaaatcc aacaaacaat taggaaaaaa tggagacgaa gagacacccc acaaaacaac aaaagacatc aaagaaattg agaagaaaag agttgctgct ttaaaaagac tagaagagat tgaacgtatt ttaaatggtg Protein function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. [The UniProt Consortium]