SUV420H1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 2658 Sequence: ATGAAGTGGT TGGGAGAATC CAAGAACATG GTGGTGAATG GCAGGAGAAA TGGAGGCAAG TTGTCTAATG ACCATCAGCA GAATCAATCA AAATTACAGC ACACGGGGAA GGACACCCTG AAGGCTGGCA AAAATGCAGT CGAGAGGAGG TCGAACAGAT GTAATGGTAA CTCGGGATTT GAAGGACAGA GTCGCTATGT ACCATCCTCT GGAATGTCCG CCAAGGAACT CTGTGAAAAT GATGACCTAG CAACCAGTTT GGTTCTTGAT CCCTATTTAG GTTTTCAAAC ACACAAAATG AATACTAGCG CCTTTCCTTC GAGGAGCTCA AGGCATTTTT CAAAATCTGA CAGTTTTTCT CACAACAACC CTGTGAGATT TAGGCCTATT AAAGGAAGGC AGGAAGAACT AAAGGAAGTA ATTGAACGTT TTAAGAAAGA TGAACACTTG GAGAAAGCCT TCAAATGTTT GACTTCAGGC GAATGGGCAC GGCACTATTT TCTCAACAAG AATAAAATGC AGGAGAAATT ATTCAAAGAA CATGTATTTA TTTATTTGCG AATGTTTGCA ACTGACAGTG GATTTGAAAT ATTGCCATGT AATAGATACT CATCAGAACA AAATGGAGCC AAAATAGTTG CAACAAAAGA GTGGAAACGA AATGACAAAA TAGAATTACT GGTGGGTTGT ATTGCCGAAC TTTCAGAAAT TGAGGAGAAC ATGCTACTTA GACATGGAGA AAACGACTTC AGTGTCATGT ACTCCACAAG GAAAAACTGT GCTCAACTCT GGCTGGGTCC TGCTGCGTTT ATAAACCATG ATTGCAGACC TAATTGTAAG TTTGTGTCAA CTGGTCGAGA TACAGCATGT GTGAAGGCTC TAAGAGACAT TGAACCTGGA GAAGAAATTT CTTGTTATTA TGGAGATGGG TTCTTTGGAG AAAATAATGA GTTCTGCGAG TGTTACACTT GCGAAAGACG GGGCACTGGT GCTTTTAAAT CCAGAGTGGG ACTGCCTGCG CCTGCTCCTG TTATCAATAG CAAATATGGA CTCAGAGAAA CAGATAAACG TTTAAATAGG CTTAAAAAGT TAGGTGACAG CAGCAAAAAT TCAGACAGTC AATCTGTCAG CTCTAACACT GATGCAGATA CCACTCAGGA AAAAAACAAT GCAACTTCTA ACCGAAAATC TTCAGTTGGC GTAAAAAAGA ATAGCAAGAG CAGAACGTTA ACGAGGCAAT CTATGTCAAG AATTCCAGCT TCTTCCAACT CTACCTCATC TAAGCTAACT CATATAAATA ATTCCAGGGT ACCAAAGAAA CTGAAGAAGC CTGCAAAGCC TTTACTTTCA AAGATAAAAT TGAGAAATCA TTGCAAGCGG CTGGAGCAAA AGAATGCTTC AAGAAAACTC GAAATGGGAA ACTTAGTACT GAAAGAGCCT AAAGTAGTTC TGTATAAAAA TTTGCCCATT AAAAAAGATA AGGAGCCAGA GGGACCAGCC CAAGCCGCAG TTGCCAGCGG GTGCTTGACT AGACACGCGG CGAGAGAACA CAGACAGAAT CCTGTGAGAG GTGCTCATTC GCAGGGGGAG AGCTCGCCCT GCACCTACAT AACTCGGCGG TCAGTGAGGA CAAGAACAAA TCTGAAGGAG GCCTCTGACA TCAAGCTTGA ACCAAATACG TTGAATGGCT ATAAAAGCAG TGTGACGGAA CCTTGCCCCG ACAGTGGTGA ACAGCTGCAG CCAGCTCCTG TGCTGCAGGA GGAAGAACTG GCTCATGAGA CTGCACAAAA AGGGGAGGCA AAGTGTCATA AGAGTGACAC AGGCATGTCC AAAAAGAAGT CACGACAAGG AAAACTTGTG AAACAGTTTG CAAAAATAGA GGAATCTACT CCAGTGCACG ATTCTCCTGG AAAAGACGAC GCGGTACCAG ATTTGATGGG TCCCCATTCT GACCAGGGTG AGCACAGTGG CACTGTGGGC GTGCCTGTGA GCTACACAGA CTGTGCTCCT TCACCCGTCG GTTGTTCAGT TGTGACATCA GATAGCTTCA AAACAAAAGA CAGCTTTAGA ACTGCAAAAA GTAAAAAGAA GAGGCGAATC ACAAGGTATG ATGCACAGTT AATCCTAGAA AATAACTCTG GGATTCCCAA ATTGACTCTT CGTAGGCGTC ATGATAGCAG CAGCAAAACA AATGACCAAG AGAATGATGG AATGAACTCT TCCAAAATAA GCATCAAGTT AAGCAAAGAC CATGACAACG ATAACAATCT CTATGTAGCA AAGCTTAATA ATGGATTTAA CTCAGGATCA GGCAGTAGTT CTACAAAATT AAAAATCCAG CTAAAACGAG ATGAGGAAAA TAGGGGGTCT TATACAGAGG GGCTTCATGA AAATGGGGTG TGCTGCAGTG ATCCTCTTTC TCTCTTGGAG TCTCGAATGG AGGTGGATGA CTATAGTCAG TATGAGGAAG AAAGTACAGA TGATTCCTCC TCTTCTGAGG GCGATGAAGA GGAGGATGAC TATGATGATG ACTTTGAAGA CGATTTTATT CCTCTTCCTC CAGCTAAGCG CTTGAGGTTA ATAGTTGGAA AAGACTCTAT AGATATTGAC ATTTCTTCAA GGAGAAGAGA AGATCAGTCT TTAAGGCTTA Protein function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys- 20' of histone H4. [The UniProt Consortium]