SUV420H1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1155 Sequence: atggtggtga atggcaggag aaatggaggc aagttgtcta atgaccatca gcagaatcaa tcaaaattac agcacacggg gaaggacacc ctgaaggctg gcaaaaatgc agtcgagagg aggtcgaaca gatgtaatgg taactcggga tttgaaggac agagtcgcta tgtaccatcc tctggaatgt ccgccaagga actctgtgaa aatgatgacc tagcaaccag tttggttctt gatccctatt taggttttca aacacacaaa atgaatacta gcgcctttcc ttcgaggagc tcaaggcatt tttcaaaatc tgacagtttt tctcacaaca accctgtgag atttaggcct attaaaggaa ggcaggaaga actaaaggaa gtaattgaac gttttaagaa agatgaacac ttggagaaag ccttcaaatg tttgacttca ggcgaatggg cacggcacta ttttctcaac aagaataaaa tgcaggagaa attattcaaa gaacatgtat ttatttattt gcgaatgttt gcaactgaca gtggatttga aatattgcca tgtaatagat actcatcaga acaaaatgga gccaaaatag ttgcaacaaa agagtggaaa cgaaatgaca aaatagaatt actggtgggt tgtattgccg aactttcaga aattgaggag aacatgctac ttagacatgg agaaaacgac ttcagtgtca tgtactccac aaggaaaaac tgtgctcaac tctggctggg tcctgctgcg tttataaacc atgattgcag acctaattgt aagtttgtgt caactggtcg agatacagca tgtgtgaagg ctctaagaga cattgaacct ggagaagaaa tttcttgtta ttatggagat gggttctttg gagaaaataa tgagttctgc gagtgttaca cttgcgaaag acggggcact ggtgctttta aatccagagt gggactgcct gcgcctgctc ctgttatcaa tagcaaatat ggactcagag aaacagataa acgtttaaat aggcttaaaa agttaggtga cagcagcaaa aattcagaca gtcaatctgt cagctctaac actgatgcag ataccactca ggaaaaaaac aatgcaagta Protein function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys- 20' of histone H4. [The UniProt Consortium]