SPTLC3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 528 Sequence: atggctaacc ctggaggtgg tgctgtttgc aacgggaaac ttcacaatca caagaaacag agcaatggct cacaaagcag aaactgcaca aagaatggaa tagtgaagga agcccagcaa aatgggaagc cacattttta tgataagctc attgttgaat cgtttgagga agcacccctt catgttatgg ttttcactta catgggatat ggaattggaa ccctgtttgg ctatctcaga gactttttaa gaaactgggg aatagaaaaa tgcaacgcag ctgtggaacg aaaagaacaa aaagtacgta tgcgcacctc cctggatctt tgtcaatgcc tactcctctc taaagtgttc tcagaagtgg tgatgcaggt gcagattcta gaaagcatga ggtgctcagg aactattcag ggcaaatttc attcatctcc acctgctaaa ccccattacc catgggctta tggacctgtt tttacaaaca tctcatgggc aactactatt tgccacatac Protein function: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1- SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1- SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference. [The UniProt Consortium]