SOX5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1929 Sequence: atgtcttcca agcgaccagc ctctccgtat ggggaagcag atggagaggt agccatggtg acaagcagac agaaagtgga agaagaggag agtgacgggc tcccagcctt tcaccttccc ttgcatgtga gttttcccaa caagcctcac tctgaggaat ttcagccagt ttctctgctg acgcaagaga cttgtggcca taggactccc acttctcagc acaatacaat ggaagttgat ggcaataaag ttatgtcttc atttgcccca cacaactcat ctacctcacc tcagaaggca gaagaaggtg ggcgacagag tggcgagtcc ttgtctagta cagccctggg aactcctgaa cggcgcaagg gcagtttagc tgatgttgtt gacaccttga agcagaggaa aatggaagag ctcatcaaaa acgagccgga agaaaccccc agtattgaaa aactactctc aaaggactgg aaagacaagc ttcttgcaat gggatcgggg aactttggcg aaataaaagg gactcccgag agcttagctg agaaagaaag gcaactcatg ggtatgatca accagctgac cagcctccga gagcagctgt tggctgccca cgatgagcag aagaaactag ctgcctctca gattgagaaa cagcgtcagc aaatggagct ggccaagcag caacaagaac aaattgcaag acagcagcag cagcttctac agcaacaaca caaaatcaat ttgctccagc aacagatcca ggttcaaggt cagctgccgc cattaatgat tcccgtattc cctcctgatc aacggacact ggctgcagct gcccagcaag gattcctcct ccctccaggc ttcagctata aggctggatg tagtgaccct taccctgttc agctgatccc aactaccatg gcagctgctg ccgcagcaac accaggctta ggcccactcc aactgcagca gttatatgct gcccagctag ctgcaatgca ggtatctcca ggagggaagc tgccaggcat accccaaggc aaccttggtg ctgctgtatc tcctaccagc attcacacag acaagagcac aaacagccca ccacccaaaa gcaaggaaaa aacaacactg gagagtctga ctcagcaact ggcagttaaa cagaatgaag aaggaaaatt tagccatgca atgatggatt tcaatctgag tggagattct gatggaagtg ctggagtctc agagtcaaga atttataggg aatcccgagg gcgtggtagc aatgaacccc acataaagcg tccaatgaat gccttcatgg tgtgggctaa agatgaacgg agaaagatcc ttcaagcctt tcctgacatg cacaactcca acatcagcaa gatattggga tctcgctgga aagctatgac aaacctagag aaacagccat attatgagga gcaagcccgt ctcagcaagc agcacctgga gaagtaccct gactataagt acaagcccag gccaaagcgc acctgcctgg tggatggcaa aaagctgcgc attggtgaat acaaggcaat catgcgcaac aggcggcagg aaatgcggca gtacttcaat gttgggcaac aagcacagat ccccattgcc actgctggtg ttgtgtaccc tggagccatc gccatggctg ggatgccctc ccctcacctg ccctcggagc actcaagcgt gtctagcagc ccagagcctg ggatgcctgt tatccagagc acttacggtg tgaaaggaga ggagccacat atcaaagaag agatacaggc cgaggacatc aatggagaaa tttatgatga gtacgacgag gaagaggatg atccagatgt agattatggg agtgacagtg aaaaccatat tgcaggacaa Protein function: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein- coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. [The UniProt Consortium]