SLC24A6 (Vector pUC, Accession No. BC098360)

Length: 1755 Sequence: ATGGCCGGCA GAAGGCTGAA TCTGCGCTGG GCACTGAGTG TGCTTTGTGT GCTGCTAATG GCGGAGACAG TGTCTGGGAC TAGGGGCTCG TCTACAGGAG CTCACATTAG CCCCCAGTTT CCAGCTTCAG GTGTGAACCA GACCCCCGTG GTAGACTGCC GCAAGGTGTG TGGCCTGAAT GTCTCTGACC GCTGTGACTT CATCCGGACC AACCCTGACT GCCACAGTGA TGGGGGGTAC CTGGACTACC TGGAAGGCAT CTTCTGCCAC TTCCCTCCCA GCCTCCTCCC TCTGGCTGTC ACTCTCTACG TTTCCTGGCT GCTCTACCTG TTTCTGATTC TGGGAGTCAC CGCAGCCAAG TTTTTCTGCC CCAACTTGTC GGCCATTTCT ACCACACTGA AGCTCTCCCA CAACGTGGCA GGCGTCACCT TCCTGGCATT TGGGAATGGT GCACCTGACA TCTTCAGTGC CCTGGTGGCC TTCTCTGACC CGCACACAGC CGGCCTGGCC CTTGGGGCAC TGTTTGGCGC TGGCGTGCTG GTTACCACAG TGGTGGCCGG AGGCATTACC ATCCTACACC CCTTCATGGC TGCCTCCAGG CCCTTCTTCA GGGACATCGT TTTCTACATG GTGGCTGTGT TCCTGACCTT CCTCATGCTC TTCCGTGGCA GGGTCACCCT GGCATGGGCT CTGGGTTACC TGGGCTTGTA TGTGTTCTAT GTGGTCACTG TGATTCTCTG CACCTGGATC TACCAACGGC AACGGAGAGG ATCTCTGTTC TGCCCCATGC CAGTTACTCC AGAGATCCTC TCAGACTCCG AGGAGGACCG GGTATCTTCT AATACCAACA GCTATGACTA CGGTGATGAG TACCGGCCGC TGTTCTTCTA CCAGGAGACC ACGGCTCAGA TCCTGGTCCG GGCCCTCAAT CCCCTGGATT ACATGAAGTG GAGAAGGAAA TCAGCATACT GGAAAGCCCT CAAGGTGTTC AAGCTGCCTG TGGAGTTCCT GCTGCTCCTC ACAGTCCCCG TCGTGGACCC GGACAAGGAT GACCAGAACT GGAAACGGCC CCTCAACTGT CTGCATCTGG TTATCAGCCC CCTGGTTGTG GTCCTGACCC TGCAGTCGGG GACCTATGGT GTCTATGAGA TAGGCGGCCT CGTTCCCGTC TGGGTCGTGG TGGTGATCGC AGGCACAGCC TTGGCTTCAG TGACCTTTTT TGCCACATCT GACAGCCAGC CCCCCAGGCT TCACTGGCTC TTTGCTTTCC TGGGCTTTCT GACCAGCGCC CTGTGGATCA ACGCGGCCGC CACAGAGGTG GTGAACATCT TGCGGTCCCT GGGTGTGGTC TTCCGGCTGA GCAACACTGT GCTGGGGCTC ACGCTGCTGG CCTGGGGGAA CAGCATTGGA GATGCCTTCT CGGATTTCAC ACTGGCTCGC CAGGGCTACC CACGGATGGC GTTCTCCGCC TGCTTTGGCG GCATCATCTT CAACATCCTC GTGGGTGTGG GGCTGGGCTG CCTGCTCCAG ATCTCCCGAA GCCACACAGA AGTGAAGCTG GAGCCAGACG GACTGCTGGT GTGGGTCCTG GCAGGCGCCC TGGGGCTCAG CCTCGTCTTC TCCCTGGTCT CAGTCCCATT GCAGTGCTTC CAGCTCAGCA GAGTCTATGG CTTCTGCCTG CTCCTCTTCT ACCTGAACTT CCTTGTCGTG GCCCTCCTCA CTGAATTTGG AGTGATTCAC CTGAAAAGCA Protein function: Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store- operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069). [The UniProt Consortium]