SENP2 (Vector pUC, Accession No. BC040609)

Length: 1770 Sequence: atgtacagat ggctggttag gattctcggc accattttcc gtttctgcga ccggtcggtg ccccctgccc gggccctcct gaagaggcgg cgctcagaca gcactctgtt ttctacagtg gacactgatg aaataccagc caaaagacca agattagatt gctttattca ccaagtgaaa aacagtctct acaatgctgc cagcttattt ggattcccat tccagctgac cacaaagccc atggtaactt ctgcttgtaa tggaacacgg aatgtggccc cttcaggaga ggtattttcg aactcttcat cttgtgaact gacaggttct ggatcctgga acaacatgct gaaactgggt aataaatctc ctaatggaat aagtgactat ccaaagatca gagtgacagt tacccgagat cagccacgca gagtcctgcc ttcctttggt tttactttga actcagaagg ctgtaataga agaccaggtg gccgtcgcca tagcaaaggt aatccagaga gttctttaat gtggaaacct caggaacagg ctgtaacaga gatgatttct gaagagagtg gcaagggtct gaggcgtccc cattgtactg tggaggaggg tgttcaaaaa gaggaaagag agaagtaccg aaagttattg gaacgactta aagaaagtgg tcatggaaac tctgtctgtc ctgtaacttc aaattatcac agttctcaaa gaagtcagat ggacacatta aagaccaaag gctgggggga agagcaaaat cacggagtca aaacaactca gtttgttcca aaacaatata gacttgttga aacaagggga cctctatgtt cattgagaag tgaaaagagg tgttcaaagg ggaaaattac tgatacagag acgatggtcg gaatcagatt tgaaaatgaa agtaggaggg gataccaact ggagcctgac ctatcagaag aagtgtcggc ccgactccgc ctgggcagtg gaagcaatgg cttactcagg aggaaagtgt caataattga gacaaaggaa aagaattgct caggcaaaga gagggacaga agaacggacg atctccttga acttacagag gacatggaaa aggaaatcag taatgcccta ggccatggcc cacaggatga aatcctaagt agtgctttca aattgcgaat tactcgagga gatattcaga cattaaagaa ctatcactgg ctcaatgatg aagtcattaa tttttacatg aatcttctgg tggaaagaaa taaaaagcaa ggctatccag cacttcatgt attcagtact ttcttctatc ctaaattaaa gtctgggggt taccaagcag tgaaacgatg gaccaaaggg gtaaatctct ttgaacaaga aattattctg gtgcctattc atcggaaggt acattggagc ctggtggtga ttgacctaag aaaaaagtgt cttaaatatc tggattctat gggacaaaag ggccacagga tctgtgagat tctccttcag tatttacagg atgaaagtaa gaccaaaaga aatagtgatc tgaatctttt agagtggacc catcacagca tgaaaccaca cgagattcct caacagctga atgggagtga ttgtggaatg tttacttgta aatatgcaga ttatatttct agggacaaac ctatcacatt tactcagcac cagatgcctc tcttccggaa gaagatggtg tgggaaatcc ttcatcagca Protein function: Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). [The UniProt Consortium]