RNF111 (Vector pUC, Accession No. BC060862)

Length: 2958 Sequence: atgtctcaat ggactcctga atataaggag ctctacacct taaaagtgga tatgaagagt gagattcctt ctgatgcacc aaagacacag gagagtctga aagggatcct tttgcatcca gagcccattg gggcagccaa aagttttcct gcaggagttg agatgattaa tagtaaagtg gggaatgaat tctctcacct gtgtgatgat tctcaaaagc aagagaagga aatgaatggt aaccagcaag aacaagaaaa aagtctcgtt gtgaggaaaa aacgcaaaag ccagcaggct ggcccttcgt atgtgcagaa ttgtgttaaa gaaaaccagg gaatattagg actgaggcaa cacctaggga caccaagtga tgaagataat gattcctctt ttagtgattg tctttcttct ccttcatcta gtctgcattt tggggattct gatactgtga cttcagatga ggataaagaa gtctctgtaa gacattccca gaccattttg aatgctaaaa gtagaagcca tagtgcacgg tctcataagt ggcctcggac tgagacagaa tctgtatcgg gattgttaat gaaaagaccc tgtttacatg gcagttcgtt acggagactt ccatgcagaa agagatttgt aaaaaataat tcctcacaga ggacacagaa acaaaaagag aggatattaa tgcagaggaa gaaacgagaa gtgttagctc gaagaaaata tgccttgcta cctagttcta gtagttccag tgagaatgac ctcagcagtg aatcctcttc tagctcatca actgaaggag aagaagattt gtttgtttct gccagtgaaa accaccaaaa caatccagct gttccctcag gaagtattga tgaagatgtt gtggtgatag aagcttcctc cactccccag gttactgcca atgaagaaat taatgttacc tcaactgaca gtgaagtgga gattgtaaca gttggagaaa gctatcggtc tcgttcaacc cttggacact ccagatctca ttggagccag ggttccagtt ctcatgcaag tcggccacag gagccacgga accgcagtag gatttctact gttatacagc ccttgaggca gaatgcagca gaagttgtgg accttaccgt tgatgaagat gaacctactg tagtaccaac cacttctgca agaatggaat cacaagctac tagcgcttcc attaacaatt caaatccatc tacctctgag caggcctctg atactgcttc agctgtcacc agtagccaac cttccacagt gtcagagact tcagctactc ttacaagcaa tagtaccact ggcacttcta taggagatga ctcaaggaga actacatcta gtgctgtaac ggaaactggc cctcctgcaa tgccaaggtt accttcctgc tgtccccagc actcaccatg tggagggtcg tcacagaacc accatgcatt aggacatcct catacaagtt gctttcagca gcatggtcac cattttcaac atcatcacca ccaccaccat actccccacc cagctgtccc agtttctcct tcctttagtg atcctgcttg ccctgtggaa agacctccac aagtacaagc accttgtgga gcaaatagta gttctggtac cagctatcat gaacaggcat tgccagtgga cctgagcaac agtggtatca gaagtcatgg aagtggcagt tttcatggag catctgcatt tgacccctgc tgccctgttt cttcctcccg agctgcaatc tttggccatc aggccgctgc tgctgcccca agtcaacctt tatcatcaat agatggctat ggatcaagca tggttgcgca gccccagccc cagccccctc cacagccctc tctctcatca tgtcgacatt acatgccacc cccttatgcc tctttgacaa ggccacttca tcatcaagct tctgcctgcc cgcattctca tggaaacccc cctcctcaga ctcagcctcc gcctcaagtg gattatgtta ttcctcatcc tgtacatgct ttccattctc aaatatcttc tcatgcaaca tctcatcctg tggcaccccc accaccaact cacttagcca gtacagctgc accaatccct cagcatcttc ctcctacaca ccagccaatt tcgcaccata ttccagccac agcacctcca gcacagagac tgcatcctca tgaagtgatg cagaggatgg aagttcaaag gaggaggatg atgcagcatc caacgcgggc acatgaacgc cccccacccc atccacatag gatgcaccca aactatggtc atgggcatca tattcatgtg cctcagacta tgtcctcaca tcctcgacag gctccagaga ggtctgcctg ggaactggga attgaagctg gagtgactgc agctacttat acacctggtg cattgcatcc tcacttggcc cattatcacg cacctcctcg acttcatcac ttacaattag gagctcttcc tttaatggtt cctgatatgg caggctatcc tcacatccgt tacatttcat caggattgga tggaacatca ttcagaggtc ctttcagggg caattttgag gaactgattc atttggaaga aagattaggc aatgtcaatc gtggagcatc ccaggggaca attgaaagat gtacatatcc acataaatac aaaaagagga aactgcactg caaacaagat ggggaagaag ggactgagga agacacagag gaaaaatgta ctatctgttt gtctatttta gaggaaggtg aagatgtgag acgtcttcca tgtatgcacc ttttccacca agtgtgtgtt gaccaatggt tgattaccaa taagaagtgc cccatatgca gagtggacat tgaggcccag ctgccaagtg Protein function: E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development. Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded. Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML. The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs). [The UniProt Consortium]