PTGES2 (Vector pUC, Accession No. BC011613)

Length: 1134 Sequence: atggacccgg ctgcgcgggt ggtgcgggcg ctgtggcctg gtgggtgcgc cttggcctgg aggctgggag gccgccccca gccgctgcta cccacgcaga gccgggctgg cttcgcgggg gcggcgggcg gcccgagccc cgtggctgca gctcgtaagg ggagcccgcg gctgctggga gctgcggcgc tggccctggg gggagccctg gggctgtacc acacggcgcg gtggcacctg cgcgcccagg acctccacgc agagcgctca gccgcgcagc tctccctgtc cagccgcctg cagctgaccc tgtaccagta caagacgtgt cccttctgca gcaaggtccg agccttcctc gacttccatg ccctgcccta ccaggtggtg gaggtgaacc ctgtgcgcag ggctgagatc aagttctcct cctacagaaa ggtgcccatc ctggtggccc aggaaggaga aagctcgcaa caactaaatg actcctctgt catcatcagc gccctcaaga cctacctggt gtcggggcag cccctggaag agatcatcac ctactaccca gccatgaagg ctgtgaacga gcagggcaag gaggtgaccg agttcggcaa taagtactgg ctcatgctca acgagaagga ggcccagcaa gtgtatggtg ggaaggaggc caggacggag gagatgaagt ggcggcagtg ggcggacgac tggctggtgc acctgatctc ccccaatgtg taccgcacgc ccaccgaggc tctggcgtcc tttgactaca ttgtccgcga gggcaagttc ggagccgtgg agggtgccgt ggccaagtac atgggtgcag cggccatgta cctcatcagc aagcgactca agagcaggca ccgcctccag gacaacgtgc gcgaggacct ctatgaggct gctgacaagt gggtggctgc tgtgggcaag gaccggccct tcatgggggg ccagaagccg aatctcgctg atttggcggt gtatggcgtg ctgcgtgtga tggaggggct ggatgcattc gatgacctga tgcagcacac gcacatccag ccctggtacc tgcgggtgga gagggccatc accgaggcct ccccagcgca Protein function: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH- dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783). [The UniProt Consortium]