PSENEN (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 306 Sequence: atgaacctgg agcgagtgtc caatgaggag aaattgaacc tgtgccggaa gtactacctg ggggggtttg ctttcctgcc ttttctctgg ttggtcaaca tcttctggtt cttccgagag gccttccttg tcccagccta cacagaacag agccaaatca aaggctatgt ctggcgctca gctgtgggct tcctcttctg ggtgatagtg ctcacctcct ggatcaccat cttccagatc taccggcccc gctggggtgc ccttggggac tacctctcct tcaccatacc cctgggcacc Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). [The UniProt Consortium]