PPP4R2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1254 Sequence: ATGGACGTCG AGAGGCTCCA GGAGGCGCTG AAAGATTTTG AGAAGAGGGG GAAAAAGGAA GTTTGTCCTG TCCTGGATCA GTTTCTTTGT CATGTAGCCA AGACTGGAGA AACAATGATT CAGTGGTCCC AATTTAAAGG CTATTTTATT TTCAAACTGG AGAAAGTGAT GGATGATTTC AGAACTTCAG CTCCTGAGCC AAGAGGTCCT CCCAACCCTA ATGTCGAATA TATTCCCTTT GATGAAATGA AGGAAAGAAT ACTGAAAATT GTCACTGGAT TTAATGGTAT CCCTTTTACT ATTCAGCGAC TATGTGAATT GTTAACAGAT CCAAGGAGAA ACTATACAGG AACAGACAAA TTTCTCAGAG GAGTAGAAAA GAATGTGATG GTTGTTAGCT GTGTTTATCC TTCTTCAGAG AAAAACAATT CCAATAGTTT AAATCGAATG AATGGTGTTA TGTTTCCTGG AAATTCACCA AGCTATACTG AGAGGTCTAA TATAAATGGG CCTGGGACAC CCAGGCCACT TAATCGACCA AAGGTTTCTT TGTCAGCCCC CATGACAACA AATGGGTTGC CTGAGAGCAC AGACAGCAAA GAGGCAAATT TGCAGCAAAA TGAGGAGAAA AATCACAGTG ACTCTTCGAC CTCTGAATCA GAAGTTTCCT CAGTGAGCCC TTTGAAAAAT AAACATCCAG ATGAAGATGC TGTGGAAGCT GAGGGGCATG AGGTAAAAAG ACTCAGGTTT GACAAAGAAG GTGAAGTCAG AGAAACAGCC AGTCAAACGA CTTCCAGCGA AATTTCTTCA GTTATGGTAG GAGAAACAGA AGCATCATCT TCATCTCAGG ATAAAGACAA AGATAGCCGT TGTACCCGGC AGCACTGTAC AGAAGAGGAT GAAGAAGAGG ATGAAGAGGA AGAAGAAGAG TCTTTTATGA CATCAAGAGA AATGATCCCA GAAAGAAAAA ATCAAGAAAA AGAATCTGAT GATGCCTTAA CTGTGAATGA AGAGACTTCT GAGGAAAATA ATCAAATGGA GGAATCTGAT GTGTCTCAAG CTGAGAAAGA TTTGCTACAT TCTGAAGGTA GTGAAAACGA AGGCCCTGTA AGTAGTAGTT CTTCTGACTG CCGTGAAACA GAAGAATTAG TAGGATCCAA TTCCAGTAAA ACTGGAGAGA TTCTTTCAGA ATCATCCATG GAAAATGATG ACGAAGCCAC AGAAGTCACC GATGAACCAA TGGAACAAGA Protein function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. [The UniProt Consortium]