PLCD4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2289 Sequence: atggcgtccc tgctgcaaga ccagctgacc actgatcagg acttgctgct gatgcaggaa ggcatgccga tgcgcaaggt gaggtccaaa agctggaaga agctaagata cttcagactt cagaatgacg gcatgacagt ctggcatgca cggcaggcca ggggcagtgc caagcccagc ttctcaatct ctgatgtgga gacaatacgt aatggccatg attccgagtt gctgcgtagc ctggcagagg agctccccct ggagcagggc ttcaccattg tcttccatgg ccgccgctcc aacctggacc tgatggccaa cagtgttgag gaggcccaga tatggatgcg agggctccag ctgttggtgg atcttgtcac cagcatggac catcaggagc gcctggacca atggctgagc gattggtttc aacgtggaga caaaaatcag gatggtaaga tgagtttcca agaagttcag cggttattgc acctaatgaa tgtggaaatg gaccaagaat atgccttcag tctttttcag gcagcagaca cgtcccagtc tggaaccctg gaaggagaag aattcgtaca gttctataag gcattgacta aacgtgctga ggtgcaggaa ctgtttgaaa gtttttcagc tgatgggcag aagctgactc tgctggaatt tttggatttc ctccaagagg agcagaagga gagagactgc acctctgagc ttgctctgga actcattgac cgctatgaac cttcagacag tggcaaactg cggcatgtgc tgagtatgga tggcttcctc agctacctct gctctaagga tggagacatc ttcaacccag cctgcctccc catctatcag gatatgactc aacccctgaa ccactacttc atctgctctt ctcataacac ctacctagtg ggggaccagc tttgcggcca gagcagcgtc gagggatata tacgggccct gaagcggggg tgccgctgcg tggaggtgga tgtatgggat ggacctagcg gggaacctgt cgtttaccac ggacacaccc tgacctcccg catcctgttc aaagatgtcg tggccacagt agcacagtat gccttccaga catcagacta cccagtcatc ttgtccctgg agacccactg cagctgggag cagcagcaga ccatggcccg tcatctgact gagatcctgg gggagcagct gctgagcacc accttggatg gggtgctgcc cactcagctg ccctcgcctg aggagcttcg gaggaagatc ctggtgaagg ggaagaagtt aacacttgag gaagacctgg aatatgagga agaggaagca gaacctgagt tggaagagtc agaattggcg ctggagtccc agtttgagac tgagcctgag ccccaggagc agaaccttca gaataaggac aaaaagaaga aatccaagcc catcttgtgt ccagccctct cttccctggt tatctacttg aagtctgtct cattccgcag cttcacacat tcaaaggagc actaccactt ctacgagata tcatctttct ctgaaaccaa ggccaagcgc ctcatcaagg aggctggcaa tgagtttgtg cagcacaata cttggcagtt aagccgtgtg tatcccagcg gcctgaggac agactcttcc aactacaacc cccaggaact ctggaatgca ggctgccaga tggtggccat gaatatgcag actgcagggc ttgaaatgga catctgtgat gggcatttcc gccagaatgg cggctgtggc tatgtgctga agccagactt cctgcgtgat atccagagtt ctttccaccc tgagaagccc atcagccctt tcaaagccca gactctctta atccaggtga tcagcggtca gcaactcccc aaagtggaca agaccaaaga ggggtccatt gtggatccac tggtgaaagt gcagatcttt ggcgttcgtc tagacacagc acggcaggag accaactatg tggagaacaa tggttttaat ccatactggg ggcagacact atgtttccgg gtgctggtgc ctgaacttgc catgctgcgt tttgtggtaa tggattatga ctggaaatcc cgaaatgact ttattggtca gtacaccctg ccttggacct gcatgcaaca aggttaccgc cacattcacc tgctgtccaa agatggcatc agcctccgcc cagcttccat ctttgtgtat atctgcatcc aggaaggcct ggagggggat Protein function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. [The UniProt Consortium]