PLA2G1B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 447 Sequence: ATGAAACTCC TTGTGCTAGC TGTGCTGCTC ACAGTGGCCG CCGCCGACAG CGGCATCAGC CCTCGGGCCG TGTGGCAGTT CCGCAAAATG ATCAAGTGCG TGATCCCGGG GAGTGACCCC TTCTTGGAAT ACAACAACTA CGGCTGCTAC TGTGGCTTGG GGGGCTCAGG CACCCCCGTG GATGAACTGG ACAAGTGCTG CCAGACACAT GACAACTGCT ATGACCAGGC CAAGAAGCTG GACAGCTGTA AATTTCTGCT GGACAACCCG TACACCCACA CCTATTCATA CTCGTGCTCT GGCTCGGCAA TCACCTGTAG CAGCAAAAAC AAAGAGTGTG AGGCCTTCAT TTGCAACTGC GACCGCAACG CTGCCATCTG CTTTTCAAAA GCTCCATATA ACAAGGCACA CAAGAACCTG GACACCAAGA AGTATTGTCA Protein function: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:10681567, PubMed:17603006). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:10681567, PubMed:17603006). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner (PubMed:7721806, PubMed:25335547). Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis (PubMed:25335547). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity. [The UniProt Consortium]