PGRMC2 (Vector pUC, Accession No. BC016692)

Length: 672 Sequence: atggcggctg gtgatgggga cgtgaagcta ggcaccctgg ggagtggcag cgagagcagc aacgacggcg gcagcgagag tccaggcgac gcgggagcgg cagcggaagg gggaggctgg gcggcggcgg cgttggcgct tctgacgggg ggcggggaaa tgctgctgaa cgtggcgctg gtggctctgg tgctgctggg ggcctaccgg ctgtgggtgc gctgggggcg gcggggtctg ggggccgggg ccggggcggg cgaggagagc cccgccacct ctctgcctcg catgaagaag cgggacttca gcttggagca gctgcgccag tacgacggct cccgcaaccc gcgcatcctg ctcgcggtca atgggaaagt cttcgacgtg accaaaggca gcaagttcta cggcccggcg ggtccatatg gaatatttgc tggtagggat gcctccagag gactggccac attttgccta gataaagatg cacttagaga tgaatatgat gatctctcag atttgaatgc agtacaaatg gagagtgttc gagaatggga aatgcagttt aaagaaaaat atgattatgt aggcagactc ctaaaaccag gagaagaacc atcagaatat acagatgaag aagataccaa ggatcacaat aaacaggatt Protein function: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. [The UniProt Consortium]