PGRMC1 (Vector pUC, Accession No. BC034238)

Length: 588 Sequence: atggctgccg aggatgtggt ggcgactggc gccgacccaa gcgatctgga gagcggcggg ctgctgcatg agattttcac gtcgccgctc aacctgctgc tgcttggcct ctgcatcttc ctgctctaca agatcgtgcg cggggaccag ccggcggcca gcggcgacag cgacgacgac gagccgcccc ctctgccccg cctcaagcgg cgcgacttca cccccgccga gctgcggcgc ttcgacggcg tccaggaccc gcgcatactc atggccatca acggcaaggt gttcgatgtg accaaaggcc gcaaattcta cgggcccgag gggccgtatg gggtctttgc tggaagagat gcatccaggg gccttgccac attttgcctg gataaggaag cactgaagga tgagtacgat gacctttctg acctcactgc tgcccagcag gagactctga gtgactggga gtctcagttc actttcaagt atcatcacgt gggcaaactg ctgaaggagg gggaggagcc cactgtgtac tcagatgagg aagaaccaaa agatgagagt gcccggaaaa Protein function: Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). [The UniProt Consortium]