PDCD6IP (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 2622 Sequence: atggcgacat tcatctcgat gcagctgaaa aagacctcag aggtggacct ggccaagccg ctggtgaagt tcatccagca gacttaccca agcggcgggg aagagcaggc ccagtactgc cgcgcggcgg aggagctcag caagctgcgc cgcgccgcag tcggtcgtcc gctggacaag cacgagggcg cgctcgagac gctcctgaga tattatgatc agatttgttc tattgaaccc aaattcccat tttctgaaaa tcagatctgc ttgacattta cctggaagga tgctttcgat aaaggttcac tttttggagg ctctgtaaaa ctggctcttg caagcttagg atatgaaaag agctgtgtgt tgttcaattg tgcagcctta gctagccaaa ttgcagcaga acagaacctg gataatgatg aaggattgaa aatcgctgct aaacattacc agtttgctag tggtgccttt ttacatatta aagagacggt tttatctgcc ttaagtcgag agccgaccgt ggacatatct ccagatactg ttgggaccct cagtcttatt atgctggcac aggctcaaga agtatttttt ttaaaagcca caagagataa aatgaaagat gccatcatag ctaaattggc taatcaggct gcagattatt ttggtgatgc tttcaaacag tgtcaataca aagatactct ccccaagtat ttttatttcc aggaggtgtt ccctgtcttg gctgcaaagc actgtatcat gcaggccaat gctgagtacc atcagtctat cctggcaaaa cagcagaaga aatttggaga agaaattgca aggttacagc atgcagcaga actgattaaa acagtggcat ctcgctatga tgaatatgtt aatgtgaagg atttttctga caaaatcaat cgtgcccttg ctgcagcaaa gaaggataat gacttcattt atcatgatcg agttccagac cttaaagatc tagatcctat tggcaaagcc acacttgtga aatctacccc ggtcaatgta cccatcagtc agaaatttac tgatctgttt gagaagatgg ttcccgtgtc agtacagcag tctttggctg cctataatca gaggaaagcc gatttgatta acagatcaat tgctcagatg agagaagcca ccactttggc aaatggggtg ctagcttccc ttaatcttcc agcagcaatt gaagatgtgt ctggagacac tgtacctcag tctatattga ctaaatccag atctgtgatt gaacagggag gcatccagac tgttgatcag ttgattaaag aactgcctga attactgcaa cgaaatagag aaatcctaga tgagtcatta aggttgttgg atgaagaaga agcaaccgat aatgatttaa gagcaaaatt taaggaacgt tggcaaagga caccatccaa tgaactgtat aagcctttaa gagcagaggg aaccaacttc agaacagttt tagataaagc tgtgcaggca gatggacaag tgaaagaatg ctaccagtct catcgtgaca ccatcgtgct tttgtgtaag ccagagcctg agctgaatgc tgccatccct tctgctaatc cagcaaagac catgcagggc agtgaggttg taaatgtctt aaaatcctta ttgtcaaatc ttgatgaagt aaagaaggaa agagagggtc tggagaatga cttgaaatct gtgaattttg acatgacaag caagtttttg acagccctgg ctcaagatgg tgtgataaat gaagaagctc tttctgttac tgaactagat cgagtctatg gaggtcttac aactaaagtc caagaatctc taaagaaaca ggagggactt cttaaaaata ttcaggtctc acatcaggaa ttttcaaaaa tgaaacaatc taataatgaa gctaacttaa gagaagaagt tttgaagaat ttagctactg catatgacaa ctttgttgaa cttgtagcta atttgaagga aggcacaaag ttttacaatg agttgactga aatcctggtc aggttccaga acaaatgcag tgatatagtt tttgcacgga agacagaaag agatgaactc ttaaaggact tgcaacaaag cattgccaga gaacctagtg ctccttcaat tcctacacct gcgtatcagt cctcaccagc aggaggacat gcaccaactc ctccaactcc agcgccaaga accatgccgc ctactaagcc ccagccccca gccaggcctc caccacctgt gcttccagca aatcgagctc cttctgctac tgctccatct ccagtggggg ctgggactgc tgcgccagct ccatcacaaa cgcctggctc agctcctcct ccacaggcgc agggaccacc ctatcccacc tatccaggat atcctgggta ttgccaaatg cccatgccca tgggctataa tccttatgcg tatggccagt ataatatgcc atatccacca gtgtatcacc agagtcctgg acaggctcca tacccgggac cccagcagcc ttcatacccc ttccctcagc ccccacagca gtcttactat ccacagcagt Protein function: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. [The UniProt Consortium]