PDCD6IP (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 2607 Sequence: atggcgacat tcatctcggt gcagctgaaa aagacctcag aggtggacct ggccaagccg ctggtgaagt tcatccagca gacttaccca agcggcgggg aagagcaggc ccagtactgc cgcgcggcgg aggagctcag caagctgcgc cgcgccgcag tcggtcgtcc gctggacaag cacgagggcg cgctcgagac gctcctgaga tattatgatc agatttgttc tattgaaccc aaattcccat tttctgaaaa tcagatctgc ttgacattta cctggaagga tgctttcgat aaaggttcac tttttggagg ctctgtaaaa ctggctcttg caagcttagg atatgaaaag agctgtgtgt tgttcaattg tgcagcctta gctagccaaa ttgcagcaga acagaacctg gataatgatg aaggattgaa aatcgctgct aaacattacc agtttgctag tggtgccttt ttacatatta aagagacggt tttatctgcc ttaagtcgag agccgaccgt ggacatatct ccagatactg ttgggaccct cagtcttatt atgctggcac aggctcaaga agtatttttt ttaaaagcca caagagataa aatgaaagat gccatcatag ctaaattggc taatcaggct gcagattatt ttggtgatgc tttcaaacag tgtcaataca aagatactct ccccaaggag gtgttccctg tcttggctgc aaagcactgt atcatgcagg ccaatgctga gtaccatcag tctatcctgg caaaacagca gaagaaattt ggagaagaaa ttgcaaggtt acagcatgca gcagaactga ttaaaacagt ggcatctcgc tatgatgaat atgttaatgt gaaggatttt tctgacaaaa tcaatcgtgc ccttgctgca gcaaagaagg ataatgactt catttatcat gatcgagttc cagaccttaa agatctagat cctattggca aagccacact tgtgaaatct accccggtca atgtacccat cagtcagaaa tttactgatc tgtttgagaa gatggttccc gtgtcagtac agcagtcttt ggctgcctat aatcagagga aagccgattt ggttaacaga tcaattgctc agatgagaga agccaccact ttggcaaatg gggtgctagc ttcccttaat cttccagcag caattgaaga tgtgtctgga gacactgtac ctcagtctat attgactaaa tccagatctg tgattgaaca gggaggcatc cagactgttg atcagttgat taaagaactg cctgaattac tgcaacgaaa tagagaaatc ctagatgagt cattaaggtt gttggatgaa gaagaagcaa ccgataatga tttaagagca aaatttaagg aacgttggca aaggacacca tccaatgaac tgtataagcc tttaagagca gagggaacca acttcagaac agttttagat aaagctgtgc aggcagatgg acaagtgaaa gaatgttacc agtctcatcg tgacaccatc gtgcttttgt gtaagccaga gcctgagctg aatgctgcca tcccttctgc taatccagca aagaccatgc agggcagtga ggttgtaaat gtcttaaaat ccttattgtc aaatcttgat gaagtaaaga aggaaagaga gggtctggag aatgacttga aatctgtgaa ttttgacatg acaagcaagt ttttgacagc cctggctcaa gatggtgtga taaatgaaga agctctttct gttactgaac tagatcgagt ctatggaggt cttacaacta aagtccaaga atctctaaag aaacaggagg gacttcttaa aaatattcag gtctcacatc aggaattttc aaaaatgaaa caatctaata atgaagctaa cttaagagaa gaagttttga agaatttagc tactgcatat gacaactttg ttgaacttgt agctaatttg aaggaaggca caaagtttta caatgagttg actgaaatcc tggtcaggtt ccagaacaaa tgcagtgata tagtttttgc acggaagaca gaaagagatg aactcttaaa ggacttgcaa caaagcattg ccagagaacc tagtgctcct tcaattccta cacctgcgta tcagtcctca ccagcaggag gacatgcacc aactcctcca actccagcgc caagaaccat gccgcctact aagccccagc ccccagccag gcctccacca cctgtgcttc cagcaaatcg agctccttct gctactgctc catctccagt gggggctggg actgctgcgc cagctccatc acaaacgcct ggctcagctc ctcctccaca ggcgcaggga ccaccctatc ccacctatcc aggatatcct gggtattgcc aaatgcccat gcccatgggc tataatcctt atgcgtatgg ccagtataat atgccatatc caccagtgta tcaccagagt cctggacagg ctccataccc gggaccccag cagccttcat accccttccc tcagccccca cagcagtctt actatccaca Protein function: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. [The UniProt Consortium]