OPRL1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1113 Sequence: atggagcccc tcttccccgc gccgttctgg gaggttatct acggcagcca ccttcagggc aacctgtccc tcctgagccc caaccacagt ctgctgcccc cgcatctgct gctcaatgcc agccacggcg ccttcctgcc cctcgggctc aaggtcacca tcgtggggct ctacctggcc gtgtgtgtcg gagggctcct ggggaactgc cttgtcatgt acgtcatcct caggcacacc aaaatgaaga cagccaccaa tatttacatc tttaacctgg ccctggccga cactctggtc ctgctgacgc tgcccttcca gggcacggac atcctcctgg gcttctggcc gtttgggaat gcgctgtgca agacagtcat tgccattgac tactacaaca tgttcaccag caccttcacc ctaactgcca tgagtgtgga tcgctatgta gccatctgcc accccatccg tgccctcgac gtccgcacgt ccagcaaagc ccaggctgtc aatgtggcca tctgggccct ggcctctgtt gtcggtgttc ccgttgccat catgggctcg gcacaggtcg aggatgaaga gatcgagtgc ctggtggaga tccctacccc tcaggattac tggggcccgg tgtttgccat ctgcatcttc ctcttctcct tcatcgtccc cgtgctcgtc atctctgtct gctacagcct catgatccgg cggctccgtg gagtccgcct gctctcgggc tcccgagaga aggaccggaa cctgcggcgc atcactcggc tggtgctggt ggtagtggct gtgttcgtgg gctgctggac gcctgtccag gtcttcgtgc tggcccaagg gctgggggtt cagccgagca gcgagactgc cgtggccatt ctgcgcttct gcacggccct gggctacgtc aacagctgcc tcaaccccat cctctacgcc ttcctggatg agaacttcaa ggcctgcttc cgcaagttct gctgtgcatc tgccctgcgc cgggacgtgc aggtgtctga ccgcgtgcgc agcattgcca aggacgtggc cctggcctgc aagacctctg agacggtacc gcggcccgca Protein function: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. [The UniProt Consortium]