NR5A2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1488 Sequence: ATGTCTTCTA ATTCAGATAC TGGGGATTTA CAAGAGTCTT TAAAGCACGG ACTTACACCT ATTGTGTCTC AATTTAAAAT GGTGAATTAC TCCTATGATG AAGATCTGGA AGAGCTTTGT CCCGTGTGTG GAGATAAAGT GTCTGGGTAC CATTATGGGC TCCTCACCTG TGAAAGCTGC AAGGGATTTT TTAAGCGAAC AGTCCAAAAT AATAAAAGGT ACACATGTAT AGAAAACCAG AACTGCCAAA TTGACAAAAC ACAGAGAAAG CGTTGTCCTT ACTGTCGTTT TCAAAAATGT CTAAGTGTTG GAATGAAGCT AGAAGCTGTA AGGGCCGACC GAATGCGTGG AGGAAGGAAT AAGTTTGGGC CAATGTACAA GAGAGACAGG GCCCTGAAGC AACAGAAAAA AGCCCTCATC CGAGCCAATG GACTTAAGCT AGAAGCCATG TCTCAGGTGA TCCAAGCTAT GCCCTCTGAC CTGACCATTT CCTCTGCAAT TCAAAACATC CACTCTGCCT CCAAAGGCCT ACCTCTGAAC CATGCTGCCT TGCCTCCTAC AGACTATGAC AGAAGTCCCT TTGTAACATC CCCCATTAGC ATGACAATGC CCCCTCACGG CAGCCTGCAA GGTTACCAAA CATATGGCCA CTTTCCTAGC CGGGCCATCA AGTCTGAGTA CCCAGACCCC TATACCAGCT CACCCGAGTC CATAATGGGC TATTCATATA TGGATAGTTA CCAGACGAGC TCTCCAGCAA GCATCCCACA TCTGATACTG GAACTTTTGA AGTGTGAGCC AGATGAGCCT CAAGTCCAGG CTAAAATCAT GGCCTATTTG CAGCAAGAGC AGGCTAACCG AAGCAAGCAC GAAAAGCTGA GCACCTTTGG GCTTATGTGC AAAATGGCAG ATCAAACTCT CTTCTCCATT GTCGAGTGGG CCAGGAGTAG TATCTTCTTC AGAGAACTTA AGGTTGATGA CCAAATGAAG CTGCTTCAGA ACTGCTGGAG TGAGCTCTTA ATCCTCGACC ACATTTACCG ACAAGTGGTA CATGGAAAGG AAGGATCCAT CTTCCTGGTT ACTGGGCAAC AAGTGGACTA TTCCATAATA GCATCACAAG CCGGAGCCAC CCTCAACAAC CTCATGAGTC ATGCACAGGA GTTAGTGGCA AAACTTCGTT CTCTCCAGTT TGATCAACGA GAGTTCGTAT GTCTGAAATT CTTGGTGCTC TTTAGTTTAG ATGTCAAAAA CCTTGAAAAC TTCCAGCTGG TAGAAGGTGT CCAGGAACAA GTCAATGCCG CCCTGCTGGA CTACACAATG TGTAACTACC CGCAGCAGAC AGAGAAATTT GGACAGCTAC TTCTTCGACT ACCCGAAATC CGGGCCATCA GTATGCAGGC TGAAGAATAC CTCTACTACA AGCACCTGAA CGGGGATGTG CCCTATAATA ACCTTCTCAT TGAAATGTTG CATGCCAAAA Protein function: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. [The UniProt Consortium]