NAPEPLD (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1182 Sequence: atggatgaaa atgaaagcaa ccagtctctg atgacaagca gccaatatcc taaagaagca gtaagaaaac gtcaaaattc agcacggaat tccggagcaa gtgattcttc taggttttct aggaaaagct tcaaactgga ttatagacta gaagaagatg taactaaatc caagaaagga aaagatggga gatttgtgaa tccgtggcca acatggaaaa acccctctat tccaaatgtt ctcagatggc tgataatgga gaaagatcac agcagtgttc caagttctaa agaggaacta gacaaagaac tcccagtgct taagccatat tttatcacta accctgaaga agctggagtg agggaagctg gcttaagagt cacatggctg ggacatgcca cggtaatggt ggaaatggat gagctcatat ttctcacgga tcccatcttt agctctcgtg cttcaccatc gcagtacatg ggtccaaagc gatttcgtcg ttccccgtgc acaataagtg aactccctcc aatagatgcg gtccttatca gtcacaacca ctatgaccat ctggactaca attctgtcat tgctttgaat gagcgatttg gtaatgagtt gagatggttt gtgcctttgg gtctccttga ctggatgcaa aaatgtggct gtgagaatgt gattgagttg gactggtggg aggagaattg tgtccccgga catgataagg tcacttttgt ctttacacct tcccagcact ggtgtaaaag gactctaatg gatgacaaca aggtgctatg gggcagctgg tctgtcttgg ggccttggaa tcgatttttt ttcgcaggag atactggtta ttgccctgct tttgaagaga taggaaaaag atttggacct tttgaccttg cagctattcc catcggagct tatgaaccga ggtggtttat gaaataccag catgtagacc cagaagaagc tgtaaggatt cacactgatg tccaaacaaa gaaatctatg gcaattcact ggggaacttt tgccttagca aatgagcatt acttagagcc tccagtgaag ctgaatgaag ctctagagag atacggactt aacgctgaag atttttttgt cttgaagcat ggagaatcaa gatacctaaa taataatgat gaaaactttt Protein function: D-type phospholipase that hydrolyzes N-acyl- phosphatidylethanolamines (NAPEs) to produce bioactive N- acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs. [The UniProt Consortium]