MCM3AP (Vector pUC, Accession No. BC104958)

Length: 5943 Sequence: atgaacccaa ctaatccttt cagtgggcag cagcctagtg ctttttcggc gtcttctagt aatgtaggaa cacttccatc taagccgcca tttcgatttg gtcaaccttc tctttttgga caaaacagta ccttatctgg gaagagctcg ggattttcac aggtatccag ctttccagcg tcttctggag taagtcattc ctcttcagtg caaacattag ggttcaccca aacctcaagt gttggaccct tttctggact tgagcacact tccacctttg tggctacctc tgggccttca agtttatctg tgctgggaaa cacaggattt agttttaaat cacccaccag tgttggggct ttcccaagca cttctgcttt tggacaagaa gctggagaaa tagtgaactc tggttttggg aaaacagaat tcagctttaa acctctggaa aatgcagtgt tcaaaccaat actgggggct gaatctgagc cagagaaaac ccagagccaa attgcttctg ggttttttac attttcccac ccaattagta gtgcacctgg aggcctggcc cctttctctt ttcctcaagt aacaagtagt tcagctacca cttcaaattt taccttttca aaacctgtta gtagtaataa ttcattatct gcctttaccc ctgctttgtc aaaccaaaat gtagaggaag agaagagagg acctaagtca atatttggaa gttctaataa tagcttcagt agcttccctg tatcatctgc ggttttgggc gaacctttcc aggctagcaa agcaggtgtc aggcaggggt gtgaagaagc tgtttcccag gtggaaccac ttcccagcct aatgaaagga ctgaaaagga aggaggacca ggatcgctcc ccaaggagac atggccacga gccagcagaa gattcggatc ctctgtcccg gggcgatcat cctccagaca aacgacctgt ccgcctgaat cgaccccggg gaggtacttt atttggtcgg acgatacagg atgttttcaa aagcaataag gaagtaggtc gtctgggcaa caaggaggcc aaaaaggaaa ctggctttgt tgagtctgca gaaagtgacc acatggctat cccaggaggg aatcagtctg tcctggcacc ttcccggatt ccaggtgtga ataaagagga agaaactgaa agtagagaga agaaagaaga ttctctaaga ggaactccgg cgcgtcagag taacagaagc gagagcacag acagtcttgg gggcttgtct ccctctgaag tcacagccat ccagtgcaag aatatccctg actacctcaa cgacaggacc attctggaga accattttgg caaaattgct aaagtgcagc gcatctttac caggcgcagc aaaaagcttg cagtggtaca tttctttgat catgcatctg cagccctggc tagaaagaag gggaaaagtt tgcataaaga catggctatc ttttggcaca ggaagaaaat aagccccaat aagaaaccct tttccctgaa ggagaagaaa ccaggtgacg gtgaagtcag cccgagcaca gaggatgcac cctttcagca ctctcctctt ggcaaggccg cagggaggac tggtgctagc agcctcctga ataaaagctc tccagtgaag aagccaagtc ttctaaaggc ccaccaattc gagggagact cttttgactc agcctccgag ggctccgagg gcctcgggcc atgtgtgctc tccctcagta ccctgatagg cactgtggct gagacatcca aggagaagta ccgcctgctt gaccagagag acaggatcat gcggcaagct cgggtgaaga gaaccgatct ggacaaagcg aggacttttg ttggcacctg cctggatatg tgtcctgaga aggagaggta catgcgggag acccgtagcc agctgagcgt gttcgaagtg gtcccaggga ctgaccaggt ggaccacgca gcagctgtga aagagtacag tcggtcctcg gcggatcagg aggagcccct gccccacgag ctgcggccct tgccagtgct cagcaggacc atggactacc tggtgaccca gatcatggac cagaaggagg gcagcctgcg ggattggtat gacttcgtgt ggaaccgcac gcgtggcata cggaaggata tcacgcagca gcacctctgt gaccccctga cggtgtccct gattgagaag tgcacccggt ttcacatcca ctgtgcccac ttcatgtgtg aggagcccat gtcctccttt gatgccaaga tcaataatga gaacatgacc aagtgcctgc agagcctgaa ggagatgtac caggacctga gaaacaaggg tgtcttctgt gccagcgaag cggagttcca gggctacaat gttctgctca gtctcaacaa gggagacatc ctaagagaag tacaacagtt ccatcctgct gttagaaact catctgaggt gaaatttgct gttcaggctt ttgctgcatt gaacagtaat aattttgtga gatttttcaa actggtccag tcagcttctt acctgaacgc ttgtctttta cactgttact tcagtcagat ccgcaaggat gctctccggg cgctcaactt tgcgtacacg gtgagcacac agcgatctac catctttccc ctggatggtg tggtgcgcat gctgctgttc agagactgtg aagaggccac cgacttcctc acctgccacg gcctcaccgt ttccgacggc tgtgtggagc tgaaccggtc tgcattcctg gaaccagagg gattatccaa gaccaggaag tcggtgttta ttactaggaa gctgacggtg tcagtcgggg aaattgtgaa cggagggcca ttgccccccg tccctcgtca tacccctgtg tgcagcttca actcccagaa caagtacatc ggggagagcc tggccgcgga gctgcccgtc agcacccaga gacccggctc cgacacagtg ggcggaggga gaggagagga gtgtggtgta gagccggatg cacccctgtc cagtctccca cagtctctac cagcccctgc gccctcacca gtgcctctgc ctcctgtcct ggcactgacc ccgtctgtgg cgcccagcct cttccagctg tctgtgcagc ctgaaccacc gcctccagag cccgtgccca tgtactctga cgaggacctg gcgcaggtgg tggacgagct catccaggag gccctgcaga gggactgtga ggaagttggc tctgcgggtg ctgcctacgc agctgccgcc ctgggtgttt ctaatgctgc tatggaggat ttgttaacag ctgcaaccac gggcattttg aggcacattg cagctgaaga agtgtctaag gaaagagagc gaagggagca ggagaggcag cgggctgaag aggaaaggtt gaaacaagag agagagctgg tgttaagtga gctgagccag ggcctggccg tggagctgat ggaacgcgtg atgatggagt ttgtgaggga aacctgctcc caggagttga agaatgcagt agagacagac cagagggtcc gtgtggcccg ttgctgtgag gatgtctgtg cccacttagt ggacttgttt ctcgtggagg aaatcttcca gactgcaaag gagaccctcc aggagcttca gtgcttctgc aagtatctac agcggtggag ggaagctgtc acagcccgca agaaactgag gcgccaaatg cgggctttcc ctgctgcgcc ctgctgcgtg gacgtgagcg accggctgag ggcgctggcg cccagcgcag agtgccccat tgctgaagag aacctggcca ggggcctcct ggacctgggc catgcaggga gattgggcat ctcctgcacc aggttaaggc ggctcagaaa caagacagct caccagatga aggttcagca cttctaccag cagctgctga gtgatgtggc atgggcgtct ctggacctgc catccctcgt ggctgagcac ctccctggga ggcaggagca tgtgttttgg aagctggtgc tggtgttgcc ggatgtagag gagcagtccc cagagagttg tggcagaatt ctagcaaatt ggttaaaagt caagttcatg ggagatgaag gctcagtgga tgacacatcc agcgatgctg gtgggattca gacgctttcg cttttcaact cacttagcag caaaggggat cagatgattt ctgttaacgt gtgtataaag gtggcccatg gcgccctcag tgatggtgcc attgatgctg tggagacaca gaaggacctc ctgggagcca gtgggctcat gctgctgctt ccccccaaaa tgaagagtga ggacatggca gaggaggacg tgtactggct gtcggccttg ctgcagctca agcagctcct gcaggctaag cccttccagc ctgcgcttcc tctggtggtt cttgtgccta gcccaggagg ggacgccgtt gagaaggaag tagaagatgg tctgatgcta caggacttgg tttcagctaa gctgatttca gattacactg ttaccgagat ccctgatacc attaatgatc tacaaggttc aactaaggtt ttgcaagcag tgcagtggct ggtttcccac tgcccccatt cccttgacct ctgctgccag actctcattc agtacgtcga agacgggatt ggccatgagt ttagtggccg ctttttccat gacagaagag agaggcgtct gggcggtctt gcttctcagg agcctggcgc catcattgag ctgtttaaca gtgtgctgca gttcctggct tctgtggtgt cctctgaaca gctgtgtgac ctgtcctggc ctgtcactga gtttgctgag gcagggggca gccggctgct tcctcacctg cactggaatg ccccagagca cctggcctgg ctgaagcagg ctgtgctcgg gttccagctt ccgcagatgg accttccacc cctgggggcc ccctggctcc ccgtgtgctc catggttgtc cagtacgcct cccagatccc cagctcacgc cagacacagc ctgtcctcca gtcccaggtg gagaacctgc tccacagaac ctactgtagg tggaagagca agagtccctc cccagtccat ggggcaggcc cctcggtcat ggagatccca tgggatgatc ttatcgcctt gtgtatcaac cacaagctga gagactggac gcccccccgg cttcctgtta catcagaggc gctgagtgaa gatggtcaga tatgtgtgta tttttttaaa aacgatttga aaaaatatga tgttcctttg tcgtgggaac aagccaggtt gcagacgcag aaggagctac agctgagaga gggacgtttg gcaataaagc cttttcatcc ttctgcaaac aattttccca taccattgct tcacatgcac cgtaactgga agaggagcac agagtgtgct caagagggga ggattcccag cacagaggat ctgatgcgag gagcttctgc tgaggagctc ttggcgcagt gtttgtcgag cagtctgctg ctggagaaag aagagaacaa gaggtttgaa gatcagcttc agcaatggtt gtctgaagac tcaggagcat ttacggattt aacttccctt cccctctatc ttcctcagac tctagtgtct ctttctcaca ctattgaacc tgtgatgaaa acatctgtaa ctactagccc acagagtgac atgatgaggg agcaactgca gctgtcagag gcgacaggaa cgtgtctagg cgaacgacta aagcacctgg aaaggctgat ccggagttca agggaagagg aagttgcctc tgagctccat ctctctgcgc tgctagacat ggtggacatt Protein function: [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). [The UniProt Consortium]