LPAR1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1095 Sequence: atggctgcca tctctacttc catccctgta atttcacagc cccagttcac agccatgaat gaaccacagt gcttctacaa cgagtccatt gccttctttt ataaccgaag tggaaagcat cttgccacag aatggaacac agtcagcaag ctggtgatgg gacttggaat cactgtttgt atcttcatca tgttggccaa cctattggtc atggtggcaa tctatgtcaa ccgccgcttc cattttccta tttattacct aatggctaat ctggctgctg cagacttctt tgctgggttg gcctacttct atctcatgtt caacacagga cccaatactc ggagactgac tgttagcaca tggctccttc gtcagggcct cattgacacc agcctgacgg catctgtggc caacttactg gctattgcaa tcgagaggca cattacggtt ttccgcatgc agctccacac acggatgagc aaccggcggg tagtggtggt cattgtggtc atctggacta tggccatcgt tatgggtgct atacccagtg tgggctggaa ctgtatctgt gatattgaaa attgttccaa catggcaccc ctctacagtg actcttactt agtcttctgg gccattttca acttggtgac ctttgtggta atggtggttc tctatgctca catctttggc tatgttcgcc agaggactat gagaatgtct cggcatagtt ctggaccccg gcggaatcgg gataccatga tgagtcttct gaagactgtg gtcattgtgc ttggggcctt tatcatctgc tggactcctg gattggtttt gttacttcta gacgtgtgct gtccacagtg cgacgtgctg gcctatgaga aattcttcct tctccttgct gaattcaact ctgccatgaa ccccatcatt tactcctacc gcgacaaaga aatgagcgcc acctttaggc agatcctctg ctgccagcgc agtgagaacc ccaccggccc cacagaaggc tcagaccgct cggcttcctc cctcaaccac accatcttgg ctggagttca cagcaatgac cactctgtgg Protein function: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA, this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. [The UniProt Consortium]