LILRA4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1302 Sequence: ATGTCGAGGC ACATATTAAA AACACTGGAG TCTGAAAACA AGGTCAAACT CTCCATCCCA TCCATGATGT GGGAACATGC AGGGCGATAT CACTGTTACT ATCAGAGCCC TGCAGGCTGG TCAGAGCCCA GCGACCCCCT GGAGCTGGTG GTGACAGCCT ACAGCAGACC CACCCTGTCC GCCCTGCCAA GCCCTGTGGT AACCTCAGGA GTGAACGTGA CCCTCCGGTG TGCCTCACGG CTGGGACTGG GCAGGTTCAC TCTGATTGAG GAAGGAGACC ACAGGCTCTC CTGGACCCTG AACTCACACC AACACAACCA TGGAAAGTTC CAGGCCCTGT TCCCCATGGG CCCCCTGACC TTCAGCAACA GGGGTACATT CAGATGCTAC GGCTATGAAA ACAACACCCC ATACGTGTGG TCGGAACCCA GTGACCCCCT GCAGCTACTG GTGTCAGGCG TGTCTAGGAA GCCCTCCCTC CTGACCCTGC AGGGCCCTGT CGTGACCCCC GGAGAGAATC TGACCCTCCA GTGTGGCTCT GATGTCGGCT ACATCAGATA CACTCTGTAC AAGGAGGGGG CCGATGGCCT CCCCCAGCGC CCTGGCCGGC AGCCCCAGGC TGGGCTCTCC CAGGCCAACT TCACCCTGAG CCCTGTGAGC CGCTCCTACG GGGGCCAGTA CAGATGCTAC GGCGCACACA ACGTCTCCTC CGAGTGGTCG GCCCCCAGTG ACCCCCTGGA CATCCTGATC GCAGGACAGA TCTCTGACAG ACCCTCCCTC TCAGTGCAGC CGGGCCCCAC GGTGACCTCA GGAGAGAAGG TGACCCTGCT GTGTCAGTCA TGGGACCCGA TGTTCACTTT CCTTCTGACC AAGGAGGGGG CAGCCCATCC CCCGTTGCGT CTGAGATCAA TGTACGGAGC TCATAAGTAC CAGGCTGAAT TCCCCATGAG TCCTGTGACC TCAGCCCACG CGGGGACCTA CAGGTGCTAC GGCTCACGCA GCTCCAACCC CTACCTGCTG TCTCACCCCA GTGAGCCCCT GGAGCTCGTG GTCTCAGGAG CAACTGAGAC CCTCAATCCA GCACAAAAGA AGTCAGATTC CAAGACTGCC CCACACCTCC AGGATTACAC AGTGGAGAAT CTCATCCGCA TGGGTGTGGC TGGCTTGGTC CTGCTGTTCC TCGGGATTCT GTTATTTGAG GCTCAGCACA GCCAGAGAAG CCCCCCAAGG TGCAGCCAGG AGGCAAACAG CAGAAAGGAC AATGCACCCT TCAGAGTGGT GGAGCCTTGG GAACAGATCT Protein function: Functions coreceptor to limit the innate immune responses to viral infections, signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). [The UniProt Consortium]