LILRA2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1401 Sequence: atgaccccca tcctcacggt cctgatctgt ctcgggctga gtctgggccc caggacccac gtgcaggcag ggcacctccc caagcccacc ctctgggctg agccaggctc tgtgatcatc cagggaagtc ctgtgaccct caggtgtcag gggagccttc aggctgagga gtaccatcta tatagggaaa acaaatcagc atcctgggtt agacggatac aagagcctgg gaagaatggc cagttcccca tcccatccat cacctgggaa cacgcagggc ggtatcactg tcagtactac agccacaatc actcatcaga gtacagtgac cccctggagc tggtggtgac aggagcctac agcaaaccca ccctctcagc tctgcccagc cctgtggtga ccttaggagg gaacgtgacc ctccagtgtg tctcacaggt ggcatttgac ggcttcattc tgtgtaagga aggagaagat gaacacccac aacgcctgaa ctcccattcc catgcccgtg ggtggtcctg ggccatcttc tccgtgggcc ccgtgagccc gagtcgcagg tggtcgtaca ggtgctatgc ttatgactcg aactctccct atgtgtggtc tctacccagt gatctcctgg agctcctggt cccaggtgtt tctaagaagc catcactctc agtgcagcca ggtcctatgg tggcccctgg ggagagcctg accctccagt gtgtctctga tgtcggctac gacagatttg ttctgtataa ggagggagaa cgtgacttcc tccagcgccc tggttggcag ccccaggctg ggctctccca ggccaacttc accctgggcc ctgtgagccc ctcccacggg ggccagtaca gatgctacag tgcacacaac ctctcctccg agtggtcggc ccccagtgac cccctggaca tcctgatcac aggacagttc tatgacagac cctctctctc ggtgcagccg gtccccacag tagccccagg aaagaacgtg accctgctgt gtcagtcacg ggggcagttc cacactttcc ttctgaccaa ggagggggca ggccatcccc cactgcatct gagatcagag caccaagctc agcagaacca ggctgaattc cgcatgggtc ctgtgacctc agcccacgtg gggacctaca gatgctacag ctcactcagc tccaacccct acctgctgtc tctccccagt gaccccctgg agctcgtggt ctcagcatcc ctaggccaac acccccagga ttacacagtg gagaatctca tccgcatggg tgtggctggc ttggtcctgg tggtcctcgg gattctgcta tttgaggctc agcacagcca gagaagccta caagatgcag ccgggaggtg Protein function: Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). [The UniProt Consortium]