HEXA (Vector pUC, Accession No. BC018927)

Length: 1590 Sequence: atgacaagtt ccaggctttg gttttcgctg ctgctggcgg cagcgttcgc aggacgggcg acggccctct ggccctggcc tcagaacttc caaacctccg accagcgcta cgtcctttac ccgaacaact ttcaattcca gtacgatgtc agctcggccg cgcagcccgg ctgctcagtc ctcgacgagg ccttccagcg ctatcgtgac ctgcttttcg gttccgggtc ttggccccgt ccttacctca cagggaaacg gcatacactg gagaagaatg tgttggttgt ctctgtagtc acacctggat gtaaccagct tcctactttg gagtcagtgg agaattatac cctgaccata aatgatgacc agtgtttact cctctctgag actgtctggg gagctctccg aggtctggag acttttagcc agcttgtttg gaaatctgct gagggcacat tctttatcaa caagactgag attgaggact ttccccgctt tcctcaccgg ggcttgctgt tggatacatc tcgccattac ctgccactct ctagcatcct ggacactctg gatgtcatgg cgtacaataa attgaacgtg ttccactggc atctggtaga tgatccttcc ttcccatatg agagcttcac ttttccagag ctcatgagaa aggggtccta caaccctgtc acccacatct acacagcaca ggatgtgaag gaggtcattg aatacgcacg gctccggggt atccgtgtgc ttgcagagtt tgacactcct ggccacactt tgtcctgggg accaggtatc cctggattac tgactccttg ctactctggg tctgagccct ctggcacctt tggaccagtg aatcccagtc tcaataatac ctatgagttc atgagcacat tcttcttaga agtcagctct gtcttcccag atttttatct tcatcttgga ggagatgagg ttgatttcac ctgctggaag tccaacccag agatccagga ctttatgagg aagaaaggct tcggtgagga cttcaagcag ctggagtcct tctacatcca gacgctgctg gacatcgtct cttcttatgg caagggctat gtggtgtggc aggaggtgtt tgataataaa gtaaagattc agccagacac aatcatacag gtgtggcgag aggatattcc agtgaactat atgaaggagc tggaactggt caccaaggcc ggcttccggg cccttctctc tgccccctgg tacctgaacc gtatatccta tggccctgac tggaaggatt tctacgtagt ggaacccctg gcatttgaag gtacccctga gcagaaggct ctggtgattg gtggagaggc ttgtatgtgg ggagaatatg tggacaacac aaacctggtc cccaggctct ggcccagagc aggggctgtt gccgaaaggc tgtggagcaa caagttgaca tctgacctga catttgccta tgaacgtttg tcacacttcc gctgtgagtt gctgaggcga ggtgtccagg cccaacccct caatgtaggc ttctgtgagc aggagtttga Protein function: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671). The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6- sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2 (PubMed:11707436). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671). [The UniProt Consortium]