HERPUD1 (Vector pUC, Accession No. BC000086)

Length: 1176 Sequence: atggagtccg agaccgaacc cgagcccgtc acgctcctgg tgaagagccc caaccagcgc caccgcgact tggagctgag tggcgaccgc ggctggagtg tgggccacct caaggcccac ctgagccgcg tctaccccga gcgtccgcgt ccagaggacc agaggttaat ttattctggg aagctgttgt tggatcacca atgtctcagg gacttgcttc caaagcagga aaaacggcat gttttgcatc tggtgtgcaa tgtgaagagt ccttcaaaaa tgccagaaat caacgccaag gtggctgaat ccacagagga gcctgctggt tctaatcggg gacagtatcc tgaggattcc tcaagtgatg gtttaaggca aagggaagtt cttcggaacc tttcttcccc tggatgggaa aacatctcaa ggcctgaagc tgcccagcag gcattccaag gcctgggtcc tggtttctcc ggttacacac cctatgggtg gcttcagctt tcctggttcc agcagatata tgcacgacag tactacatgc aatatttagc agccactgct gcatcagggg cttttgttcc accaccaagt gcacaagaga tacctgtggt ctctgcacct gctccagccc ctattcacaa ccagtttcca gctgaaaacc agcctgccaa tcagaatgct gctcctcaag tggttgttaa tcctggagcc aatcaaaatt tgcggatgaa tgcacaaggt ggccctattg tggaagaaga tgatgaaata aatcgagatt ggttggattg gacctattca gcagctacat tttctgtttt tctcagtatc ctctacttct actcctccct gagcagattc ctcatggtca tgggggccac cgttgttatg tacctgcatc acgttgggtg gtttccattt agaccgaggc cggttcagaa cttcccaaat gatggtcctc ctcctgacgt tgtaaatcag gaccccaaca ataacttaca ggaaggcact gatcctgaaa ctgaagaccc caaccacctc cctccagaca gggatgtact agatggcgag cagaccagcc cctcctttat gagcacagca tggcttgtct tcaagacttt ctttgcctct cttcttccag aaggcccccc agccatcgca Protein function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin- mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). [The UniProt Consortium]