H2AFY (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1119 Sequence: atgtcgagcc gcggtgggaa gaagaagtcc accaagacgt ccaggtctgc caaagcagga gtcatctttc ccgtggggcg gatgctgcgg tacatcaaga aaggccaccc caagtacagg attggagtgg gggcacccgt gtacatggcc gccgtcctgg aatacctgac agcggagatt ctggagctgg ctggcaatgc agcgagagac aacaagaagg gacgggtcac accccggcac atcctgctgg ctgtggccaa tgatgaagag ctgaatcagc tgctaaaagg agtcaccata gccagtgggg gtgtgttacc caacatccac cccgagttgc tagcgaagaa gcggggatcc aaaggaaagt tggaagccat catcacacca cccccagcca aaaaggccaa gtctccatcc cagaagaagc ctgtatctaa aaaagcagga ggcaagaaag gggcccggaa atccaagaag aagcagggtg aagtcagtaa ggcagccagc gccgacagca caaccgaggg cacacctgcc gacggcttca cagtcctctc caccaagagc ctcttccttg gccagaagct gaaccttatt cacagtgaaa tcagtaattt agccggcttt gaggtggagg ccataatcaa tcctaccaat gctgacattg accttaaaga tgacctagga aacacgctgg agaagaaagg tggcaaggag tttgtggaag ctgtcctgga actccggaaa aagaacgggc ccttggaagt agctggagct gctgtcagcg caggccatgg cctgcctgcc aagtttgtga tccactgtaa tagtccagtt tggggtgcag acaagtgtga agaacttctg gaaaagacag tgaaaaactg cttggccctg gctgatgata agaagctgaa atccattgca tttccatcca tcggcagcgg caggaacggt tttccaaagc agacagcagc tcagctgatt ctgaaggcca tctccagtta cttcgtgtct acaatgtcct cttccatcaa aacggtgtac ttcgtgcttt ttgacagcga gagtataggc atctatgtgc aggaaatggc caagctggac Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). [The UniProt Consortium]