GPS1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1584 Sequence: atgagggata gctcggcccc cagctcggcc tcctcgtcag tgacagatct gtactgcacc cctcacagca gtaggtcaga cctcgtcctg cccggcacgg ccggggactt cagcctgagc gccagcctgt cggcctgtac gctgctctac gagggggccg tggagcccat gcagatcgac gtggaccccc aggaagaccc gcagaatgca cctgacgtca actacgtggt ggagaacccc agcctggatc tggaacagta cgcggccagc tacagcggcc tgatgcgcat cgaacggctg cagttcattg ctgatcactg ccccacgctg cgggtggagg ccctgaagat ggccctctcc ttcgtgcaga gaacctttaa cgtggacatg tacgaggaga tccaccgcaa gctctcagag gccaccaggg agctgcagaa cgcacccgac gccatccctg agagcggcgt ggagccccca gccctggaca cggcctgggt ggaggccacg cggaagaagg cgctgctgaa gctggagaag ctggacacag acctgaagaa ctacaagggc aactccatca aagagagcat ccggcgcggc cacgacgacc tgggcgacca ctacctggac tgtggggacc tcagcaacgc cctcaagtgc tattcccggg cccgggacta ctgcaccagc gccaaacacg tcatcaacat gtgcctcaat gtcatcaagg tcagcgtcta cttgcagaat tggtctcatg tgctcagcta cgtcagcaag gctgagtcca ccccagagat tgccgagcag cgaggagagc gtgacagcca gacccaggcc atcctcacca agctcaagtg tgccgcaggc ttggcagagc tggccgccag gaagtacaag caggctgcca agtgcctcct gctggcttcc tttgatcact gtgacttccc tgagctgctg tcccccagca acgtggccat ctacggtggc ctgtgcgcct tggctacctt tgaccggcag gagctgcagc gcaatgtcat ctccagcagc tccttcaagt tgttcttgga gctggagcca caggtccgag acatcatctt caaattctac gagtccaagt acgcctcatg tctcaagatg ctggacgaga tgaaggacaa cctgctcctg gacatgtatc tggcccccca tgtcaggacc ctgtacaccc agattcgcaa ccgtgccctc atccagtatt tcagccccta cgtgtcagcc gacatgcata ggatggcggc agccttcaat accacggtgg ccgccctgga ggacgagctg acgcagctaa tcctggaggg gctgatcagt gcccgtgtgg actcacacag caagatccta tacgcccggg acgtggatca gcgcagcacc acctttgaga agtctctgtt gatgggcaag gagttccagc gccgcgccaa ggccatgatg ctgcgggcag ctgtgctccg caaccagatc catgtcaagt ccccgcccag agaagggagc cagggggagc tgactccagc caacagccag tcccggatga gcaccaacat Protein function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. [The UniProt Consortium]