GABRB3 (Vector pUC, Accession No. BC010641)

Length: 1422 Sequence: atgtggggcc ttgcgggagg aaggcttttc ggcatcttct cggccccggt gctggtggct gtggtgtgct gcgcccagag tgtgaacgat cccgggaaca tgtcctttgt gaaggagacg gtggacaagc tgttgaaagg ctacgacatt cgcctaagac ccgacttcgg gggtcccccg gtctgcgtgg ggatgaacat cgacatcgcc agcatcgaca tggtttccga agtcaacatg gattatacct taaccatgta ttttcaacaa tattggagag ataaaaggct cgcctattct gggatccctc tcaacctcac gcttgacaat cgagtggctg accagctatg ggtgcccgac acatatttct taaatgacaa aaagtcattt gtgcatggag tgacagtgaa aaaccgcatg atccgtcttc accctgatgg gacagtgctg tatgggctca gaatcaccac gacagcagca tgcatgatgg acctcaggag ataccccctg gacgagctga actgcactct ggaaattgaa agctatggct acaccacgga tgacattgag ttttactggc gaggcgggga caaggctgtt accggagtgg aaaggattga gctcccgcag ttctccatcg tggagcaccg tctggtctcg aggaatgttg tcttcgccac aggtgcctat cctcgactgt cactgagctt tcggttgaag aggaacattg gatacttcat tcttcagact tatatgccct ctatactgat aacgattctg tcgtgggtgt ccttctggat caattatgat gcatctgctg ctagagttgc cctcgggatc acaactgtgc tgacaatgac aaccatcaac acccaccttc gggagacctt gcccaaaatc ccctatgtca aagccattga catgtacctt atgggctgct tcgtctttgt gttcctggcc cttctggagt atgcctttgt caactacatt ttctttggaa gaggccctca aaggcagaag aagcttgcag aaaagacagc caaggcaaag aatgaccgtt caaagagcga aagcaaccgg gtggatgctc atggaaatat tctgttgaca tcgctggaag ttcacaatga aatgaatgag gtctcaggcg gcattggcga taccaggaat tcagcaatat cctttgacaa ctcaggaatc cagtacagga aacagagcat gcctcgagaa gggcatgggc gattcctggg ggacagaagc ctcccgcaca agaagaccca tctacggagg aggtcttcac agctcaaaat taaaatacct gatctaaccg atgtgaatgc catagacaga tggtccagga tcgtgtttcc attcactttt tctcttttca acttagttta ctggctgtac tatgttaact Protein function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception. [The UniProt Consortium]