FIP1L1 (Vector pUC, Accession No. BC052959)

Length: 1680 Sequence: ATGATCACTT CAGATTTTCA TAATACTAGT TTCTTTAAGA GTGGTTTCTT TATTTTGTTT GCTTATTTAT TTATTTGTTT ATTTTACTTG GTAGATGAAA ATGAAGTTGA AAGGCCAGAA GAAGAAAATG CCAGTGCTAA TCCTCCATCT GGAATTGAAG ATGAAACTGC TGAAAATGGT GTACCAAAAC CGAAAGTGAC TGAGACCGAA GATGATAGTG ATAGTGACAG CGATGATGAT GAAGATGATG TTCATGTCAC TATAGGAGAC ATTAAAACGG GAGCACCACA GTATGGGAGT TATGGTACAG CACCTGTAAA TCTTAACATC AAGACAGGGG GAAGAGTTTA TGGAACTACA GGGACAAAAG TCAAAGGAGT AGACCTTGAT GCACCTGGAA GCATTAATGG AGTTCCACTC TTAGAGGTAG ATTTGGATTC TTTTGAAGAT AAACCATGGC GTAAACCTGG TGCTGATCTT TCTGATTATT TTAATTATGG GTTTAATGAA GATACCTGGA AAGCTTACTG TGAAAAACAA AAGAGGATAC GAATGGGACT TGAAGTTATA CCAGTAACCT CTACTACAAA TAAAATTACG GTACAGCAGG GAAGAACTGG AAACTCAGAG AAAGAAACTG CCCTTCCATC TACAAAAGCT GAGTTTACTT CTCCTCCTTC TTTGTTCAAG ACTGGGCTTC CACCGAGCAG AAACAGCACT TCTTCTCAGT CTCAGACAAG TACTGCCTCC AGAAAAGCCA ATTCAAGCGT TGGGAAGTGG CAGGATCGAT ATGGGAGGGC CGAATCACCT GATCTAAGGA GATTACCTAG GGCAATTGAT GTTATCGGTC AGACTATAAC TATCAGCCGA GTAGAAGGCA GGCGACGGGC AAATGAGAAC AGCAACATAC AGGTCCTTTC TGAAAGATCT GCTACTGAAG TAGACAACAA TTTTAGCAAA CCACCTCCGT TTTTCCCTCC AGGAGCTCCT CCCACTCACC TTCCACCTCC TCCATTTCTT CCACCTCCTC CGACTGTCAG CACTGCTCCA CCTCTGATTC CACCACCGGG TTTTCCTCCT CCACCAGGCG CTCCACCTCC ATCTCTTATA CCAACAATAG AAAGTGGACA TTCCTCTGGT TATGATAGTC GTTCTGCACG TGCATTTCCA TATGGCAATG TTGCCTTTCC CCATCTTCCT GGTTCTGCTC CTTCGTGGCC TAGTCTTGTG GACACCAGCA AGCAGTGGGA CTATTATGCC AGAAGAGAGA AAGACCGAGA TAGAGAGAGA GACAGAGACA GAGAGCGAGA CCGTGATCGG GACAGAGAAA GAGAACGCAC CAGAGAGAGA GAGAGGGAGC GTGATCACAG TCCTACACCA AGTGTTTTCA ACAGCGATGA AGAACGATAC AGATACAGGG AATATGCAGA AAGAGGTTAT GAGCGTCACA GAGCAAGTCG AGAAAGAGAA GAACGACATA GAGAAAGACG ACACAGGGAG AAAGAGGAAA CCAGACATAA GTCTTCTCGA AGTAATAGTA GACGTCGCCA TGAAAGTGAA GAAGGAGATA GTCACAGGAG ACACAAACAC AAAAAATCTA AAAGAAGCAA AGAAGGAAAA GAAGCGGGCA GTGAGCCTGC CCCTGAACAG GAGAGCACCG AAGCTACACC Protein function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. [The UniProt Consortium]