FCHSD2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1548 Sequence: atgcagaagt tggctagtca atacctgaag agagattggc ctggagtaaa agctgatgat cggaatgatt acaggagcat gtatcccgtt tggaaatctt ttctcgaggg aacaatgcag gtagcccagt ctcggatgaa tatatgtgaa aactataaaa acttcatttc tgagcctgca aggacagtga gaagcttaaa agaacagcaa ctaaaaaggt gtgtggacca gttgacaaag atccaaactg aattacaaga gacagtgaaa gatttagcta aaggcaaaaa gaaatacttt gagactgaac agatggctca tgcagtacga gagaaagctg acatcgaggc aaaatctaaa cttagtcttt ttcaatcaag aatcagttta cagaaggcaa gtgtaaagtt aaaagcccgg cgatctgagt gtaattccaa agctacccac gcaaggaatg attatcttct taccctagcg gcagcaaatg cacatcagga tcgctactat caaacagatt tagttaacat tatgaaggct cttgatggaa atgtgtatga tcatctcaag gattatttaa tagccttcag ccggactgag ctagaaacat gccaagctgt gcagaacaca ttccagtttt tattagaaaa ctccagcaag gtggtccggg actacaatct tcagctgttt ttgcaagaaa acgctgtatt tcacaaaccc cagcccttcc agttccagcc ttgtgacagt gatactagcc gacagttaga atcagaaact gggaccacag aggagcacag tctaaataag gaagctcgaa aatgggccac acgtgtggca cgtgagcata aaaacattgt tcaccaacaa cgggttctaa atgatctgga gtgtcatgga gctgctgtat cagaacaaag ccgagcagag ctagaacaga aaatagatga agctagagaa aatattcgta aagcagagat aattaaattg aaagctgaag cccggttgga cctgctaaag cagattggtg tttctgtgga cacatggcta aagagtgcca tgaaccaagt aatggaagaa ctggaaaatg agcgatgggc ccgccctcct gcagtgacca gtaatggcac tttacactcg cttaatgcag ataccgaaag agaagaaggc gaagagtttg aagataacat ggatgttttc gatgacagca gttccagccc ttctggcacc ttaagaaatt atccactcac ctgcaaagtt gtttattcct acaaggcttc tcaaccagat gagttgacca ttgaggaaca tgaggtgtta gaagtgattg aagatggaga tatggaagac tgggtaaagg ctcgaaataa agttggccaa gtgggttatg tgccagaaaa gtacctacag tttcccacct cgaacagcct cctgagcatg ctgcagtccc tggccgcttt ggacagtcgg tcacacacgt ccagcaattc cacggaagca gaactcgttt caggcagcct caacggagat gccagtggta Protein function: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). [The UniProt Consortium]