FCHO2 (Vector pENTR223.1, Accession No. BC014311)

Length: 1131 Sequence: atggcgtatt tcgtcgagaa tttttggggg gaaaaaaata gtggctttga tgtcctctac cataatatga aacatggaca gatatcgaca aaagaactag cagattttgt aagggaacga gctaccatag aggaggcata ctccaggtca atgacaaaac tagcaaaatc tgcaagcaat tattcacaac ttggaacatt tgcaccagta tgggatgtat tcaaaacatc tacagagaaa ttagcaaatt gtcacttgga tcttgttaga aaattacaag aattaataaa ggaagttcag aagtatggag aagaacaagt aaagtctcat aaaaagacta aagaagaagt tgcaggaact ctggaagctg tccaaaccat tcagagcata actcaggccc tccagaaatc caaggaaaat tacaatgcca agtgtgtaga acaggagcgt ttgaaaaagg aaggagctac acaaagagaa atagaaaagg cagctgttaa atctaagaaa gctacagata cttataaact ctatgtggaa aaatatgcat tagcaaaagc tgatttcgaa cagaaaatga cagaaacagc tcagaaattt caagatattg aagaaactca tctcattcac ataaaggaaa ttataggatc cttgtcaaat gctataaagg aaattcattt gcagataggc caggtccatg aagaatttat aaataacatg gctaatacta cagttgaaag tttgatacaa aaatttgctg agtcaaaagg cactgggaag gaaagacctg gcctcattga atttgaagaa tgtgacactg ctagtgcagt tgaaggtata aaaccaagga aaagaaagac ctttgctttg ccaggaatca ttaaaaagga aaaagatgca gaatctgtat ggagtttcac tgttgttgcc caggttggaa tgcaatggcg cgatcttggc ttactgcatt ctccacctcc caggttcaag cgattctcct cctacctcag cctcccaagt agctggaatt acggcgccca ccaccacatc tggctaattt tttgtatttt tagtagagac agggtttcac catattggcc aggctggtcg cgaactcctg acctcaggtg Protein function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2- dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. [The UniProt Consortium]