FBXO3 (Vector pENTR223.1, Accession No. BC046110)

Length: 1416 Sequence: atggcggcca tggagaccga gacggcgccg ctgaccctag agtcgctgcc caccgatccc ctgctcctca tcttatcctt tttggactat cgggatctaa tcaactgttg ttatgtcagt cgaagactta gccagctatc aagtcatgat ccgctgtgga gaagacattg caaaaaatac tggctgatat ctgaggaaga gaaaacacag aagaatcagt gttggaaatc tctcttcata gatacttact ctgatgtagg aagatacatt gaccattatg ctgctattaa aaaggcctgg gatgatctca agaaatattt ggagcccagg tgtcctcgga tggttttatc tctgaaagag ggtgctcgag aggaagacct cgatgctgtg gaagcgcaga ttggctgcaa gcttcctgac gattatcgat gttcataccg aattcacaat ggacagaagt tagtggttcc tgggttattg ggaagcatgg cactgtctaa tcactatcgt tctgaagatt tgttagacgt cgatacagct gccggaggat tccagcagag acagggactg aaatactgtc tccctttaac tttttgcata catactggtt tgagtcagta catagcagtg gaagctgcag agggccgaaa caaaaatgaa gttttctacc aatgtccaga ccaaatggct cgaaatccag ctgctattga catgtttatt ataggtgcta cttttactga ctggtttacc tcttatgtca aaaatgttgt atcaggtggc ttccccatca tcagagacca aattttcaga tatgttcacg atccagaatg tgtagcaaca actggggata ttactgtgtc agtttccaca tcgtttctgc cagaacttag ctctgtacat ccaccccact atttcttcac ataccgaatc aggattgaaa tgtcaaaaga tgcacttcct gagaaggcct gtcagttgga cagtcgctat tggagaataa caaatgctaa gggtgacgtg gaagaagttc aaggacctgg agtagttggt gaatttccaa tcatcagccc aggtcgggta tatgaataca caagctgtac cacattctct acaacatcag gatacatgga aggatattat accttccatt ttctttactt taaagacaag atctttaatg ttgccattcc ccgattccat atggcatgtc caacattcag ggtgtctata gcccgattgg aaatgggtcc tgatgaatat gaagagatgg aagaagagga ggaggaggaa gaggaggaag acgaggatga tgattcagca gatatggatg aatcagatga agatgatgaa gaggagagac ggaggagagt ctttgatgtt cccattcgca gacgccgctg ctcacgcctt Protein function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. [The UniProt Consortium]