EXOSC4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 738 Sequence: atggcggggc tggagctctt gtcggaccag ggctaccggg tggacgggcg gcgcgccggg gagctgcgca agatccaggc gcggatgggc gtgttcgcgc aggctgacgg ctcggcctac attgagcagg gcaacaccaa ggcactggct gtggtctacg gcccgcacga gatccggggc tcccgggctc gagccctgcc ggacagggcc ctagtgaact gtcaatatag ttcagcgacc ttcagcacag gtgagcgcaa gcgacggcca catggggacc gtaagtcctg tgagatgggc ctgcagctcc gccagacttt cgaagcagcc atcctcacac agctgcaccc acgctcccag attgatatct atgtgcaggt gctacaggca gatggtggga cctatgcagc ttgtgtgaat gcagccacgc tggcagtgct ggatgccggg atacccatga gagactttgt gtgtgcgtgc tcagctggct tcgtggacgg cacagccctg gcggacctca gccatgtgga ggaagcagct ggtggccccc agctggccct ggccctgctg ccagcctcag gacagattgc gctgcttgag atggatgccc ggctgcacga ggaccacctg gagcgggtgt tggaggctgc tgcccaggct gcccgagatg tgcacaccct cttagatcga gtggtccggc agcatgtgcg tgaggcctct atcttgctgg Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. [The UniProt Consortium]