ERO1L (Vector pENTR223.1, Accession No. BC012941)

Length: 1407 Sequence: atgggccgcg gctggggatt cttgtttggc ctcctgggcg ccgtgtggct gctcagctcg ggccacggag aggagcagcc cccggagaca gcggcacaga ggtgcttctg ccaggttagt ggttacttgg atgattgtac ctgtgatgtt gaaaccattg atagatttaa taactacagg cttttcccaa gactacaaaa acttcttgaa agtgactact ttaggtatta caaggtaaac ctgaagaggc cgtgtccttt ctggaatgac atcagccagt gtggaagaag ggactgtgct gtcaaaccat gtcaatctga tgaagttcct gatggaatta aatctgcgag ctacaagtat tctgaagaag ccaataatct cattgaagaa tgtgaacaag ctgaacgact tggagcagtg gatgaatctc tgagtgagga aacacagaag gctgttcttc agtggaccaa gcatgatgat tcttcagata acttctgtga agctgatgac attcagtccc ctgaagctga atatgtagat ttgcttctta atcctgagcg ctacactggt tacaagggac cagatgcttg gaaaatatgg aatgtcatct acgaagaaaa ctgttttaag ccacagacaa ttaaaagacc tttaaatcct ttggcttctg gtcaagggac aagtgaagag aacacttttt acagttggct agaaggtctc tgtgtagaaa aaagagcatt ctacagactt atatctggcc tacatgcaag cattaatgtg catttgagtg caagatatct tttacaagag acctggttag aaaagaaatg gggacacaac attacagaat ttcaacagcg atttgatgga attttgactg aaggagaagg tccaagaagg cttaagaact tgtattttct ctacttaata gaactaaggg ctttatccaa agtgttacca ttcttcgagc gcccagattt tcaactcttt actggaaata aaattcagga tgaggaaaac aaaatgttac ttctggaaat acttcatgaa atcaagtcat ttcctttgca ttttgatgag aattcatttt ttgctgggga taaaaaagaa gcacacaaac taaaggagga ctttcgactg cattttagaa atatttcaag aattatggat tgtgttggtt gttttaaatg tcgtctgtgg ggaaagcttc agactcaggg tttgggcact gctctgaaga tcttattttc tgagaaattg atagcaaata tgccagaaag tggacctagt tatgaattcc atctaaccag acaagaaata gtatcattat tcaacgcatt tggaagaatt tctacaagtg tgaaagaatt agaaaacttc aggaacttgt tacagaatat Protein function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP- dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. [The UniProt Consortium]