ENTPD5 (Vector pUC, Accession No. BC130487)

Length: 1287 Sequence: atggccactt cttggggcac agtctttttc atgctggtgg tatcctgtgt ttgcagcgct gtctcccaca ggaaccagca gacttggttt gagggtatct tcctgtcttc catgtgcccc atcaatgtca gcgccagcac cttgtatgga attatgtttg atgcagggag cactggaact cgaattcatg tttacacctt tgtgcagaaa atgccaggac agcttccaat tctagaaggg gaagtttttg attctgtgaa gccaggactt tctgcttttg tagatcaacc taagcagggt gctgagaccg ttcaagggct cttagaggtg gccaaagact caatcccccg aagtcactgg aaaaagaccc cagtggtcct aaaggcaaca gcaggactac gcttactgcc agaacacaaa gccaaggctc tgctctttga ggtaaaggag atcttcagga agtcaccttt cctggtacca aagggcagtg ttagcatcat ggatggatcc gacgaaggca tattagcttg ggttactgtg aattttctga caggtcagct gcatggccac agacaggaga ctgtggggac cttggaccta gggggagcct ccacccaaat cacgttcctg ccccagtttg agaaaactct ggaacaaact cctaggggct acctcacttc ctttgagatg tttaacagca cttataagct ctatacacat agttacttgg gatttggatt gaaagctgca agactagcaa ccctgggagc cctggagaca gaagggactg atgggcacac tttccggagt gcctgtttac cgagatggtt ggaagcagag tggatctttg ggggtgtgaa ataccagtat ggtggcaacc aagaagggga ggtgggcttt gagccctgct atgccgaagt gctgagggtg gtacgaggaa aacttcacca gccagaggag gtccagagag gttccttcta tgctttctct tactattatg accgagctgt tgacacagac atgattgatt atgaaaaggg gggtatttta aaagttgaag attttgaaag aaaagccagg gaagtgtgtg ataacttgga aaacttcacc tcaggcagtc ctttcctgtg catggatctc agctacatca cagccctgtt aaaggatggc tttggctttg cagacagcac agtcttacag ctcacaaaga aagtgaacaa catagagacg ggctgggcct tgggggccac ctttcacctg ttgcagtctc tgggcatctc Protein function: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. [The UniProt Consortium]