DYRK2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1587 Sequence: atgaatgatc acctgcatgt cggcagccac gctcacggac agatccaggt tcaacagttg tttgaggata acagtaacaa gcggacagtg ctcacgacac aaccaaatgg gcttacaaca gtgggcaaaa cgggcttgcc agtggtgcca gagcggcagc tggacagcat tcatagacgg caggggagct ccacctctct aaagtccatg gaaggcatgg ggaaggtgaa agccaccccc atgacacctg aacaagcaat gaagcaatac atgcaaaaac tcacagcctt cgaacaccat gagattttca gctaccctga aatatatttc ttgggtctaa atgctaagaa gcgccagggc atgacaggtg ggcccaacaa tggtggctat gatgatgacc agggatcata tgtgcaggtg ccccacgatc acgtggctta caggtatgag gtcctcaagg tcattgggaa ggggagcttt gggcaggtgg tcaaggccta cgatcacaaa gtccaccagc acgtggccct aaagatggtg cggaatgaga agcgcttcca ccggcaagca gcggaggaga tccgaatcct ggaacacctg cggaagcagg acaaggataa cacaatgaat gtcatccata tgctggagaa tttcaccttc cgcaaccaca tctgcatgac gtttgagctg ctgagcatga acctctatga gctcatcaag aagaataaat tccagggctt cagtctgcct ttggttcgca agtttgccca ctcgattctg cagtgcttgg atgctttgca caaaaacaga ataattcact gtgaccttaa gcccgagaac attttgttaa agcagcaggg tagaagcggt attaaagtaa ttgattttgg ctccagttgt tacgagcatc agcgtgtcta cacgtacatc cagtcgcgtt tttaccgggc tccagaagtg atccttgggg ccaggtatgg catgcccatt gatatgtgga gcctgggctg cattttagca gagctcctga cgggttaccc cctcttgcct ggggaagatg aaggggacca gctggcctgt atgattgaac tgttgggcat gccctcacag aaactgctgg atgcatccaa acgagccaaa aattttgtga gctccaaggg ttatccccgt tactgcactg tcacgactct ctcagatggc tctgtggtcc taaacggagg ccgttcccgg agggggaaac tgaggggccc accggagagc agagagtggg gtaacgcgct gaaggggtgt gatgatcccc ttttccttga cttcttaaaa cagtgtttag agtgggatcc tgcagtgcgc atgaccccag gccaggcttt gcggcacccc tggctgagga ggcggttgcc aaagcctccc accggggaga aaacgtcagt gaaaaggata actgagagca ccggtgctat cacatctata tccaagttac ctccaccttc tagctcagct tccaaactga ggactaattt ggcgcagatg acagatgcca atgggaatat tcagcagagg acagtgttgc caaaacttgt Protein function: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). [The UniProt Consortium]