CYP3A5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1509 Sequence: atggacctca tcccaaattt ggcggtggaa acctggcttc tcctggctgt cagcctggtg ctcctctatc tatatgggac ccgtacacat ggacttttta agagactggg aattccaggg cccacacctc tgcctttgtt gggaaatgtt ttgtcctatc gtcagggtct ctggaaattt gacacagagt gctataaaaa gtatggaaaa atgtggggaa cgtatgaagg tcaactccct gtgctggcca tcacagatcc cgacgtgatc agaacagtgc tagtgaaaga atgttattct gtcttcacaa atcgaaggtc tttaggccca gtgggattta tgaaaagtgc catctcttta gctgaggatg aagaatggaa gagaatacgg tcattgctgt ctccaacctt caccagcgga aaactcaagg agatgttccc catcattgcc cagtatggag atgtattggt gagaaacttg aggcgggaag cagagaaagg caagcctgtc accttgaaag acatctttgg ggcctacagc atggatgtga ttactggcac atcatttgga gtgaacatcg actctctcaa caatccacaa gacccctttg tggagagcac taagaagttc ctaaaatttg gtttcttaga tccattattt ctctcaataa tactctttcc attccttacc ccagtttttg aagcattaaa tgtctctctg tttccaaaag ataccataaa ttttttaagt aaatctgtaa acagaatgaa gaaaagtcgc ctcaacgaca aacaaaagca ccgactagat ttccttcagc tgatgattga ctcccagaat tcgaaagaaa ctgagtccca caaagctctg tctgatctgg agctcgcagc ccagtcaata atcttcattt ttgctggcta tgaaaccacc agcagtgttc tttccttcac tttatatgaa ctggccactc accctgatgt ccagcagaaa ctgcaaaagg agattgatgc agttttgccc aataaggcac cacctaccta tgatgccgtg gtacagatgg agtaccttga catggtggtg aatgaaacac tcagattatt cccagttgct attagacttg agaggacttg caagaaagat gttgaaatca atggggtatt cattcccaaa gggtcaatgg tggtgattcc aacttatgct cttcaccatg acccaaagta ctggacagag cctgaggagt tccgccctga aaggttcagt aagaagaagg acagcataga tccttacata tacacaccct ttggaactgg acccagaaac tgcattggca tgaggtttgc tctcatgaac atgaaacttg ctctaatcag agtccttcag aacttctcct tcaaaccttg taaagaaaca cagatcccct tgaaattaga cacgcaagga cttcttcaac cagaaaaacc cattgttcta aaggtggatt caagagatgg aaccctaagt Protein function: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta- estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans- retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228). [The UniProt Consortium]