CYP2C18 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1473 Sequence: atggatccag ctgtggctct ggtgctctgt ctctcctgtt tgtttctcct ttcactctgg aggcagagct ctggaagagg gaggctcccg tctggcccca ctcctctccc gattattgga aatatcctgc agttagatgt taaggacatg agcaaatcct taaccaattt ctcaaaagtc tatggccctg tgttcactgt gtattttggc ctgaagccca ttgtggtgtt gcatggatat gaagcagtga aggaggccct gattgatcat ggagaggagt tttctggaag aggaagtttt ccagtggctg aaaaagttaa caaaggactt ggaatccttt tcagcaatgg aaagagatgg aaggagatcc ggcgtttctg cctcatgact ctgcggaatt ttgggatggg gaagaggagc atcgaggacc gtgttcaaga ggaagcccgc tgccttgtgg aggagttgag aaaaaccaat gcctcaccct gtgatcccac tttcatcctg ggctgtgctc cctgcaatgt gatctgctct gttattttcc atgatcgatt tgattataaa gatcagaggt ttcttaactt gatggaaaaa ttcaatgaaa acctcaggat tctgagctct ccatggatcc aggtctgcaa taatttccct gctctcatcg attatctccc aggaagtcat aataaaatag ctgaaaattt tgcttacatt aaaagttatg tattggagag aataaaagaa catcaagaat ccctggacat gaacagtgct cgggacttta ttgattgttt cctgatcaaa atggaacagg aaaagcacaa tcaacagtct gaatttactg ttgaaagctt gatagccact gtaactgata tgtttggggc tggaacagag acaacgagca ccactctgag atatggactc ctgctcctgc tgaagtaccc agaggtcaca gctaaagtcc aggaagagat tgaatgtgta gttggcagaa accggagccc ctgtatgcag gacaggagtc acatgcccta cacagatgct gtggtgcacg agatccagag atacattgac ctcctcccca ccaacctgcc ccatgcagtg acctgtgatg ttaaattcaa aaactacctc atccccaagg gcacgaccat aataacatcc ctgacttctg tgctgcacaa tgacaaagaa ttccccaacc cagagatgtt tgaccctggc cactttctgg ataagagtgg caactttaag aaaagtgact acttcatgcc tttctcagca ggaaaacgga tgtgtatggg agagggcctg gcccgcatgg agctgttttt attcctgacc accattttgc agaactttaa cctgaaatct caggttgacc caaaggatat tgacatcacc cccattgcca atgcatttgg tcgtgtgcca cccttgtacc agctctgctt cattcctgtc Protein function: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4- hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR, NADPH- ferrihemoprotein reductase). [The UniProt Consortium]