CTH (Vector pENTR223.1, Accession No. BC015807)

Length: 1218 Sequence: atgcaggaaa aagacgcctc ctcacaaggt ttcctgccac acttccaaca tttcgccacg caggcgatcc atgtgggcca ggatccagag caatggacct ccagggctgt agtgcccccc atctcactgt ccaccacgtt caagcaaggg gcgcctggcc agcactcggg ttttgaatat agccgttctg gaaatcccac taggaattgc cttgaaaaag cagtggcagc actggatggg gctaagtact gtttggcctt tgcttcaggt ttagcagcca ctgtaactat tacccatctt ttaaaagcag gagaccaaat tatttgtatg gatgatgtgt atggaggtac aaacaggtac ttcaggcaag tggcatctga atttggatta aagatttctt ttgttgattg ttccaaaatc aaattactag aggcagcaat tacaccagaa accaagcttg tttggatcga aacccccaca aaccccaccc agaaggtgat tgacattgaa ggctgtgcac atattgtcca taagcatgga gacattattt tggtcgtgga taacactttt atgtcaccat atttccagcg ccctttggct ctgggagctg atatttctat gtattctgca acaaaataca tgaatggcca cagtgatgtt gtaatgggcc tggtgtctgt taattgtgaa agccttcata atagacttcg tttcttgcaa aactctcttg gagcagttcc atctcctatt gattgttacc tctgcaatcg aggtctgaag actctacatg tccgaatgga aaagcatttc aaaaacggaa tggcagttgc ccagttcctg gaatctaatc cttgggtaga aaaggttatt tatcctgggc tgccctctca tccacagcat gagttggtga agcgtcagtg tacaggttgt acagggatgg tcacctttta tattaagggc actcttcagc atgctgagat tttcctcaag aacctaaagc tatttactct ggccgagagc ttgggaggat tcgaaagcct tgctgagctt ccggcaatca tgactcatgc atcagttctt aagaatgaca gagatgtcct tggaattagt gacacactga ttcgactttc tgtgggctta gaggatgagg aagacctact ggaagatcta gatcaagctt tgaaggcagc acaccctcca agtggaagtc Protein function: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. [The UniProt Consortium]