CNOT8 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 879 Sequence: atgcctgcag cacttgtgga gaatagccag gttatctgtg aagtgtgggc cagtaatcta gaagaagaga tgaggaagat ccgagaaatc gtgctcagtt acagttatat tgccatggac acagaatttc caggtgttgt ggtgcgacca attggtgaat ttcgtagttc catagattac caatatcagc ttctgcggtg caatgttgac cttttaaaaa ttatccagct gggccttaca ttcacaaatg agaagggaga gtatccttct ggaatcaata cttggcagtt caatttcaaa tttaacctta cagaggacat gtactcccag gattccatag atctccttgc taactcagga ctacagtttc agaagcatga agaggaaggg attgacacac tgcactttgc agagctgctt atgacatcag gagtggttct ctgtgacaat gtcaaatggc tttcatttca tagtggctat gattttggct atatggtaaa gttgcttaca gattctcgtt tgccagaaga ggaacatgaa ttctttcata ttctgaacct tttcttccca tccatttatg atgtgaaata cctgatgaag agctgcaaaa atcttaaggg aggtcttcag gaagttgctg atcagttgga tttgcagagg attggaaggc agcaccaggc aggctcagac tcactgctga caggaatggc tttctttagg atgaaagagt tgttttttga ggacagcatt gatgatgcca agtactgtgg gcggctctat ggcttaggca caggagtggc ccagaagcag aatgaggatg tggactctgc ccaggagaag atgagcatcc tggcgattat caacaacatg Protein function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. [The UniProt Consortium]