CCNT2 (Vector pUC, Accession No. BC114366)

Length: 1992 Sequence: ATGGCGTCGG GCCGTGGAGC TTCTTCTCGC TGGTTCTTTA CTCGGGAACA GCTGGAGAAC ACGCCGAGCC GCCGCTGCGG AGTGGAGGCG GATAAAGAGC TCTCGTGCCG CCAGCAGGCG GCCAACCTCA TCCAGGAGAT GGGACAGCGT CTCAATGTCT CTCAGCTTAC AATAAACACT GCGATTGTTT ATATGCACAG GTTTTATATG CACCATTCTT TCACCAAATT CAACAAAAAT ATAATATCGT CTACTGCATT ATTTTTGGCT GCAAAAGTGG AAGAACAGGC TCGAAAACTT GAACATGTTA TCAAAGTAGC ACATGCTTGT CTTCATCCTC TAGAGCCACT GCTGGATACT AAATGTGATG CTTACCTTCA ACAGACTCAA GAACTGGTTA TACTTGAAAC CATAATGCTA CAAACTCTAG GTTTTGAGAT CACCATTGAA CACCCACACA CAGATGTGGT GAAATGTACC CAGTTAGTAA GAGCAAGCAA GGATTTGGCA CAGACATCCT ATTTCATGGC TACCAACAGT CTGCATCTTA CAACCTTCTG TCTTCAGTAC AAACCAACAG TGATAGCATG TGTATGCATT CATTTGGCTT GCAAATGGTC CAATTGGGAG ATCCCTGTAT CAACTGATGG AAAGCATTGG TGGGAATATG TGGATCCTAC AGTTACTCTA GAATTATTAG ATGAGCTAAC ACATGAGTTT CTACAAATAT TGGAGAAAAC GCCTAATAGG TTGAAGAAGA TTCGAAACTG GAGGGCTAAT CAGGCAGCTA GGAAACCAAA AGTAGATGGA CAGGTATCAG AGACACCACT TCTTGGTTCA TCTTTGGTCC AGAATTCCAT TTTAGTAGAT AGTGTCACTG GTGTGCCTAC AAACCCAAGT TTTCAGAAAC CATCTACATC AGCATTCCCT GCGCCAGTAC CTCTAAATTC AGGAAATATT TCTGTTCAAG ACAGCCATAC ATCTGATAAT TTGTCAATGC TAGCAACAGG AATGCCAAGT ACTTCATACG GTTTATCATC ACACCAGGAA TGGCCTCAAC ATCAAGACTC AGCAAGGACA GAACAGCTAT ATTCACAGAA ACAGGAGACA TCTTTGTCTG GTAGCCAGTA CAACATCAAC TTCCAGCAGG GACCTTCTAT ATCACTGCAT TCAGGATTAC ATCACAGACC TGACAAAATT TCAGATCATT CTTCTGTTAA GCAAGAATAT ACTCATAAAG CAGGGAGCAG TAAACACCAT GGGCCAATTT CCACTACTCC AGGAATAATT CCTCAGAAAA TGTCTTTAGA TAAATATAGA GAAAAGCGTA AACTAGAAAC TCTTGATCTC GATGTAAGGG ATCATTATAT AGCTGCCCAG GTAGAACAGC AGCACAAACA AGGGCAGTCA CAGGCAGCCA GCAGCAGTTC TGTTACTTCT CCCATTAAAA TGAAAATACC TATCGCAAAT ACTGAAAAAT ACATGGCAGA TAAAAAGGAA AAGAGTGGGT CACTGAAATT ACGGATTCCA ATACCACCCA CTGATAAAAG CGCCAGTAAA GAAGAACTGA AAATGAAAAT AAAAGTTTCT TCTTCAGAAA GACACAGCTC TTCTGATGAA GGCAGTGGGA AAAGCAAACA TTCAAGCCCA CATATTAGCA GAGACCATAA GGAGAAGCAC AAGGAGCATC CTTCAAGCCG CCACCACACC AGCAGCCACA AGCATTCCCA CTCGCATAGT GGCAGCAGCA GCGGTGGCAG TAAACACAGT GCCGACGGAA TACCACCCAC TGTTCTGAGG AGTCCTGTTG GCCTGAGCAG TGATGGCATT TCCTCTAGCT CCAGCTCTTC AAGGAAGAGG CTGCATGTCA ATGATGCATC TCACAACCAC CACTCCAAAA TGAGCAAAAG TTCCAAAAGT TCAGGTGGGC TACGGACATC TCAGCACCCT CGTGAAACTG GACAAGAAGC CAGTGGAGAC CAACGGTCCT Protein function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II. In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development. [The UniProt Consortium]