CBX2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 636 Sequence: atggaggagc tgagcagcgt gggcgagcag gtcttcgccg ccgagtgcat cctgagcaag cggctccgca agggcaagct ggagtacctg gtcaagtggc gcggctggtc ctccaaacat aacagctggg agccggagga gaacatcctg gacccgaggc tgctcctggc cttccagaag aaggaacatg agaaggaggt gcagaaccgg aagagaggca agaggccgag aggccggcca aggaagctca ctgccatgtc ctcctgcagc cggcgctcca agctcaaggt gggtggctgc gctgggtatg ctgaccccac ctcccagcac ccccttggcg tagggggcag gcagagggag ggtttggggc cctcaggaag ggggtggcac ttctgccaac agtctgtccc tctactcgga aaacaggagc cccctttctt cctgtctctc agcttctgct gccaggggcc ccagccggct gagagttcct ccccgcccct cccaggggct tcctgcttca gcctgtcctg cacgcctctc tgctgggtgg cagggtcaaa ctgctgcaga caagcactct tccctcccag ggggtccttg ggggacggaa aggaacagga agcatgcgta Protein function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). [The UniProt Consortium]