CAMK1 (Vector pUC, Accession No. BC106755)

Length: 1113 Sequence: ATGCTGGGGG CAGTGGAAGG CCCCAGGTGG AAGCAGGCGG AGGACATTAG AGACATCTAC GACTTCCGAG ATGTTCTGGG CACGGGGGCC TTCTCGGAGG TGATCCTGGC AGAAGATAAG AGGACGCAGA AGCTGGTGGC CATCAAATGC ATTGCCAAGG AGGCCCTGGA GGGCAAGGAA GGCAGCATGG AGAATGAGAT TGCTGTCCTG CACAAGATCA AGCACCCCAA CATTGTAGCC CTGGATGACA TCTATGAGAG TGGGGGCCAC CTCTACCTCA TCATGCAGCT GGTGTCGGGT GGGGAGCTCT TTGACCGTAT TGTGGAAAAA GGCTTCTACA CGGAGCGGGA CGCCAGCCGC CTCATCTTCC AGGTGCTGGA TGCTGTGAAA TACCTGCATG ACCTGGGCAT TGTACACCGG GATCTCAAGC CAGAGAATCT GCTGTACTAC AGCCTGGATG AAGACTCCAA AATCATGATC TCCGACTTTG GCCTCTCCAA GATGGAGGAC CCGGGCAGTG TGCTCTCCAC CGCCTGTGGA ACTCCGGGAT ACGTGGCCCC TGAAGTCCTG GCCCAGAAGC CCTACAGCAA GGCTGTGGAT TGCTGGTCCA TAGGTGTCAT CGCCTACATC TTGCTCTGCG GTTACCCTCC CTTCTATGAC GAGAATGATG CCAAACTCTT TGAACAGATT TTGAAGGCCG AGTACGAGTT TGACTCTCCT TACTGGGACG ACATCTCTGA CTCTGCCAAA GATTTCATCC GGCACTTGAT GGAGAAGGAC CCAGAGAAAA GATTCACCTG TGAGCAGGCC TTGCAGCACC CATGGATTGC AGGAGATACA GCTCTAGATA AGAATATCCA CCAGTCGGTG AGTGAGCAGA TCAAGAAGAA CTTTGCCAAG AGCAAGTGGA AGCAAGCCTT CAATGCCACG GCTGTGGTGC GGCACATGAG GAAACTGCAG CTGGGCACCA GCCAGGAGGG GCAGGGGCAG ACGGCGAGCC ATGGGGAGCT GCTGACACCA GTGGCTGGGG GGCCGGCAGC TGGCTGTTGC TGTCGAGACT GCTGCGTGGA GCCGGGCACA GAACTGTCCC CCACACTGCC CCACCAGCTC Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser- 92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. [The UniProt Consortium]