ATP6V0D1 (Vector pUC, Accession No. BC008861)

Length: 1056 Sequence: atgtcgttct tcccggagct ttactttaac gtggacaatg gctacttgga gggactggtg cgcggcctga aggccggggt gctcagccag gccgactacc tcaacctggt gcagtgcgag acgctagagg acttgaaact gcatctgcag agcactgatt atggtaactt cctggccaac gaggcatcac ctctgacggt gtcagtcatc gatgaccggc tcaaggagaa gatggtggtg gagttccgcc acatgaggaa ccatgcctat gagccactcg ccagcttcct agacttcatt acttacagtt acatgatcga caacgtgatc ctgctcatca caggcacgct gcaccagcgc tccatcgctg agctcgtgcc caagtgccac ccactaggca gcttcgagca gatggaggcc gtgaacattg ctcagacacc tgctgagctc tacaatgcca ttctggtgga cacgcctctt gcggcttttt tccaggactg catttcagag caggaccttg acgagatgaa catcgagatc atccgcaaca ccctctacaa ggcctacctg gagtccttct acaagttctg caccctactg ggcgggacta cggctgatgc catgtgcccc atcctggagt ttgaagcaga ccgccgcgcc ttcatcatca ccatcaattc tttcggcaca gagctgtcca aagaggaccg tgccaagctc tttccacact gtgggcggct ctaccctgag ggcctggcgc agctggctcg ggctgacgac tatgaacagg tcaagaacgt ggccgattac tacccggagt acaagctgct cttcgagggt gcaggtagca accctggaga caagacgctg gaggaccgat tctttgagca cgaggtaaag ctgaacaagt tggccttcct gaaccagttc cactttggtg tcttctatgc cttcgtgaag ctcaaggagc aggagtgtcg caacatcgtg tggatcgctg aatgtatcgc ccagcgccac cgcgccaaaa tcgacaacta catccctatc Protein function: Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed:28296633, PubMed:30374053). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed:30374053). May play a role in coupling of proton transport and ATP hydrolysis. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. [The UniProt Consortium]